open access

Vol 13, No 3 (2017)
Case report
Published online: 2017-09-08
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Radical chemotherapy of massively disseminated testicular cancer in a 24-year-old patient with acute renal failure and cancer cachexia — case report

Andrzej Witkoś, Angelika Copija, Ewa Nowakowska-Zajdel
DOI: 10.5603/OCP.2017.0016
·
Oncol Clin Pract 2017;13(3):138-140.

open access

Vol 13, No 3 (2017)
CASE REPORTS
Published online: 2017-09-08

Abstract

We present a case of a 24-year-old patient with metastatic testicular cancer, with massive dissemination to the lung, mediastinum, and abdominal organs, generalised lymphadenopathy, and accompanying acute renal failure due to the compression of the ureters by lymph node conglomerates. The patient underwent radical chemotherapy — initially at doses adequate for renal function together with periodically applied haemodialysis, subsequently in full doses. Two lines of the chemotherapy were applied. The cycles were administered according to the planned rhythm with no deferrals. The applied treatment resulted in relief of the symptoms of the disease and partial regression of the lesions in imaging studies. The persistent lesions have presented no signs of progression since November 2016 to the present day.

Abstract

We present a case of a 24-year-old patient with metastatic testicular cancer, with massive dissemination to the lung, mediastinum, and abdominal organs, generalised lymphadenopathy, and accompanying acute renal failure due to the compression of the ureters by lymph node conglomerates. The patient underwent radical chemotherapy — initially at doses adequate for renal function together with periodically applied haemodialysis, subsequently in full doses. Two lines of the chemotherapy were applied. The cycles were administered according to the planned rhythm with no deferrals. The applied treatment resulted in relief of the symptoms of the disease and partial regression of the lesions in imaging studies. The persistent lesions have presented no signs of progression since November 2016 to the present day.

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Keywords

testicular cancer, radical chemotherapy, acute renal failure

About this article
Title

Radical chemotherapy of massively disseminated testicular cancer in a 24-year-old patient with acute renal failure and cancer cachexia — case report

Journal

Oncology in Clinical Practice

Issue

Vol 13, No 3 (2017)

Article type

Case report

Pages

138-140

Published online

2017-09-08

DOI

10.5603/OCP.2017.0016

Bibliographic record

Oncol Clin Pract 2017;13(3):138-140.

Keywords

testicular cancer
radical chemotherapy
acute renal failure

Authors

Andrzej Witkoś
Angelika Copija
Ewa Nowakowska-Zajdel

References (6)
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  2. Oldenburg J, Fosså SD, Nuver J, et al. ESMO Guidelines Working Group. Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013; 24 Suppl 6: vi125–vi132.
  3. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol. 1997; 15(2): 594–603.
  4. Kimakura M, Abe T, Nagahara A, et al. Metastatic testicular cancer presenting with liver and kidney dysfunction treated with modified BEP chemotherapy combined with continuous hemodiafiltration and rasburicase. Anticancer Drugs. 2016; 27(4): 364–368.
  5. Superfin D, Iannucci AA, Davies AM. Commentary: Oncologic drugs in patients with organ dysfunction: a summary. Oncologist. 2007; 12(9): 1070–1083.
  6. Levi F, La Vecchia C, Boyle P, et al. Western and eastern European trends in testicular cancer mortality. Lancet. 2001; 357(9271): 1853–1854.

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