open access

Vol 13, No 2 (2017)
Review paper
Published online: 2017-08-25
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Practical aspects of pertuzumab treatment in patients with breast cancer — management of the most common adverse events

Roman Dubiański, Anna Górniak
DOI: 10.5603/OCP.2017.0010
·
Oncol Clin Pract 2017;13(2):61-66.

open access

Vol 13, No 2 (2017)
REVIEW ARTICLES
Published online: 2017-08-25

Abstract

Treatment outcomes of patients diagnosed with breast cancer with overexpression of the HER2 receptor have been significantly improved by the use of pertuzumab. Its use, however, is associated with the occurrence of various, more or less severe, adverse events. Some of them had already been observed in clinical practice during treatment with another monoclonal antibody directed against the HER2 receptor, trastuzumab. New toxicities, which occurred in a higher grade or significantly more frequently during treatment with pertuzumab are diarrhoea, neutropaenia and febrile neutropaenia, and skin toxicities. Their severity is generally acceptable, and proper management in the case of their occurrence is crucial for optimal causal treatment. This paper proposes schemes for management of the most common adverse events during the use of pertuzumab.

Abstract

Treatment outcomes of patients diagnosed with breast cancer with overexpression of the HER2 receptor have been significantly improved by the use of pertuzumab. Its use, however, is associated with the occurrence of various, more or less severe, adverse events. Some of them had already been observed in clinical practice during treatment with another monoclonal antibody directed against the HER2 receptor, trastuzumab. New toxicities, which occurred in a higher grade or significantly more frequently during treatment with pertuzumab are diarrhoea, neutropaenia and febrile neutropaenia, and skin toxicities. Their severity is generally acceptable, and proper management in the case of their occurrence is crucial for optimal causal treatment. This paper proposes schemes for management of the most common adverse events during the use of pertuzumab.

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Keywords

pertuzumab, breast cancer, HER2, toxicity

About this article
Title

Practical aspects of pertuzumab treatment in patients with breast cancer — management of the most common adverse events

Journal

Oncology in Clinical Practice

Issue

Vol 13, No 2 (2017)

Article type

Review paper

Pages

61-66

Published online

2017-08-25

DOI

10.5603/OCP.2017.0010

Bibliographic record

Oncol Clin Pract 2017;13(2):61-66.

Keywords

pertuzumab
breast cancer
HER2
toxicity

Authors

Roman Dubiański
Anna Górniak

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