open access

Vol 13, No 2 (2017)
Case report
Published online: 2017-08-25
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A rare case of an extranodal head and neck lymphoma primarily diagnosed as sarcoma

Aleksandra E. Danieluk, Joanna H. Mańdziuk, Marek Z. Wojtukiewicz, Ewa Sierko
DOI: 10.5603/OCP.2017.0011
·
Oncol Clin Pract 2017;13(2):67-70.

open access

Vol 13, No 2 (2017)
CASE REPORT
Published online: 2017-08-25

Abstract

Diffuse large B-cell lymphomas-not otherwise specified (DLBCL-NOS) are a common lymphoid malignancy, being the most common form of non-Hodgkin lymphoma (NHL). Typically, DLBCL-NOS arises in lymph nodes, however primarily extranodal involvement is possible, and it can present itself in various clinical and morphological types, posing a diagnostic challenge. In some cases, extranodal lymphomas may mimic non-lymphoid tumours, among them sarcomas. Treatment of DLBCL may involve chemotherapy, immunotherapy, radiotherapy and autologous stem cell transplant, while in the care of sarcomas surgery is an important modality of treatment. A-36-year-old male patient presented with a tumour of the left angle of the mandible which appeared a few days after a tooth extraction. It was first diagnosed as inflammation and treated with antibiotics. Afterwards, a biopsy indicated liposarcoma. A repeated biopsy and histopathological examination at an oncology centre revealed extranodal diffuse large B-cell lymphoma- not otherwise specified (DLBCL-NOS). The patient was successfully treated with chemotherapy with rituximab and radiotherapy. Complete remission was achieved and the patient remains DLBCL-NOS free for over six years. It is vital for extranodal lymphomas to be thoroughly differentiated from other malignancies by experienced oncology centres, since a false diagnosis may lead to a dramatic mistreatment.

Abstract

Diffuse large B-cell lymphomas-not otherwise specified (DLBCL-NOS) are a common lymphoid malignancy, being the most common form of non-Hodgkin lymphoma (NHL). Typically, DLBCL-NOS arises in lymph nodes, however primarily extranodal involvement is possible, and it can present itself in various clinical and morphological types, posing a diagnostic challenge. In some cases, extranodal lymphomas may mimic non-lymphoid tumours, among them sarcomas. Treatment of DLBCL may involve chemotherapy, immunotherapy, radiotherapy and autologous stem cell transplant, while in the care of sarcomas surgery is an important modality of treatment. A-36-year-old male patient presented with a tumour of the left angle of the mandible which appeared a few days after a tooth extraction. It was first diagnosed as inflammation and treated with antibiotics. Afterwards, a biopsy indicated liposarcoma. A repeated biopsy and histopathological examination at an oncology centre revealed extranodal diffuse large B-cell lymphoma- not otherwise specified (DLBCL-NOS). The patient was successfully treated with chemotherapy with rituximab and radiotherapy. Complete remission was achieved and the patient remains DLBCL-NOS free for over six years. It is vital for extranodal lymphomas to be thoroughly differentiated from other malignancies by experienced oncology centres, since a false diagnosis may lead to a dramatic mistreatment.

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Keywords

lymphoma, non-Hodgkin, extranodal, mandible, diagnostic errors

About this article
Title

A rare case of an extranodal head and neck lymphoma primarily diagnosed as sarcoma

Journal

Oncology in Clinical Practice

Issue

Vol 13, No 2 (2017)

Article type

Case report

Pages

67-70

Published online

2017-08-25

DOI

10.5603/OCP.2017.0011

Bibliographic record

Oncol Clin Pract 2017;13(2):67-70.

Keywords

lymphoma
non-Hodgkin
extranodal
mandible
diagnostic errors

Authors

Aleksandra E. Danieluk
Joanna H. Mańdziuk
Marek Z. Wojtukiewicz
Ewa Sierko

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