open access

Vol 12, No 6 (2016)
Case report
Published online: 2017-06-02
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Paraneoplastic Cushing’s syndrome in a patient with small cell lung cancer: case report

Anna Zadrożna-Nowak, Sylwia Dębska-Szmich, Urszula Czernek, Magdalena Krakowska, Piotr Potemski
DOI: 10.5603/OCP.2016.0018
·
Oncol Clin Pract 2016;12(6):215-217.

open access

Vol 12, No 6 (2016)
CASE REPORT
Published online: 2017-06-02

Abstract

We discuss the case of small-cell lung cancer patient with clinical features of paraneoplastic Cushing’s syndrome. The primary symptoms included electrolyte imbalance, glucose intolerance, and increased oedemas of the lower extremities. In January 2016, the patient's performance status was 2 in ECOG scale and antineoplastic treatment with carboplatin and etoposide was initiated. Following the 2nd chemotherapy cycle symptoms of paraneoplastic syndrome significantly were alleviated and performance status improved (grade 1), allowing a change of chemotherapy protocol to a more standard one (cisplatin and etoposide). At the time of the subsequent chemotherapy cycles the patent's good general condition was maintained. Use of causative treatment allowed achievement of significant clinical improvement and recovery of laboratory values.

Abstract

We discuss the case of small-cell lung cancer patient with clinical features of paraneoplastic Cushing’s syndrome. The primary symptoms included electrolyte imbalance, glucose intolerance, and increased oedemas of the lower extremities. In January 2016, the patient's performance status was 2 in ECOG scale and antineoplastic treatment with carboplatin and etoposide was initiated. Following the 2nd chemotherapy cycle symptoms of paraneoplastic syndrome significantly were alleviated and performance status improved (grade 1), allowing a change of chemotherapy protocol to a more standard one (cisplatin and etoposide). At the time of the subsequent chemotherapy cycles the patent's good general condition was maintained. Use of causative treatment allowed achievement of significant clinical improvement and recovery of laboratory values.

Get Citation

Keywords

small-cell lung cancer, paraneoplastic syndrome, Cushing’s syndrome

About this article
Title

Paraneoplastic Cushing’s syndrome in a patient with small cell lung cancer: case report

Journal

Oncology in Clinical Practice

Issue

Vol 12, No 6 (2016)

Article type

Case report

Pages

215-217

Published online

2017-06-02

DOI

10.5603/OCP.2016.0018

Bibliographic record

Oncol Clin Pract 2016;12(6):215-217.

Keywords

small-cell lung cancer
paraneoplastic syndrome
Cushing’s syndrome

Authors

Anna Zadrożna-Nowak
Sylwia Dębska-Szmich
Urszula Czernek
Magdalena Krakowska
Piotr Potemski

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