Vol 12, No 3 (2016)
Case report
Published online: 2016-08-31
Page views 325
Article views/downloads 1027
Get Citation

Connect on Social Media

Connect on Social Media

Role of immunohistochemical analysis in the diagnosis of gastric carcinosarcoma, a rare tumour — case report

Shafaq Maqsood
Oncol Clin Pract 2016;12(3):105-107.

Abstract

Carcinosarcoma is a malignant tumour that has carcinomatous and sarcomatous components occurring rarely in the stomach with only a handful of case reports, mainly from Japan. We report a case of carcinosarcoma in a fifty-two-year-old female with clinical and histopathological features. The patient underwent complete workup followed by surgical resection. Macroscopically, the tumour was large and ulcerating. Microscopically, it was a carcinosarcoma with myogenic differentiation. Immunohistochemical analysis was done, which led to the diagnosis of gastric carcinosarcoma.
Carcinosarcoma can mimic an adenocarcinoma clinically, and making a diagnosis on the basis of endoscopy or radiology alone is not possible. Our case report highlights the importance of immunohistochemical analysis in the diagnosis of gastric carcinosarcoma.

References

  1. Cirocchi R, Trastulli S, Desiderio J, et al. Gastric carcinosarcoma: A case report and review of the literature. Oncol Lett. 2012; 4(1): 53–57.
  2. Choi KW, Lee WY, Hong SW, et al. Carcinosarcoma of the stomach: a case report. J Gastric Cancer. 2013; 13(1): 69–72.
  3. Shin H, Ju J, Moon H, et al. A Rare Case of Gastric Carcinosarcoma with Neuroendocrine Differentiation. Korean J Helicobacter Up Gastrointest Res. 2014; 14(2): 121–125.
  4. Cho KJ, Myong NH, Choi DW, et al. Carcinosarcoma of the stomach. A case report with light microscopic, immunohistochemical, and electron microscopic study. APMIS. 1990; 98(11): 991–995.
  5. Ikeda Y, Kosugi SI, Nishikura K, et al. Gastric carcinosarcoma presenting as a huge epigastric mass. Gastric Cancer. 2007; 10(1): 63–68.
  6. Gohongi T, Iida H, Gunji N, et al. Postsurgical radiation therapy for gastric carcinosarcoma with c-kit expression: a case report. World J Gastroenterol. 2015; 21(9): 2830–2835.
  7. Randjelovic T, Filipovic B, Babic D, et al. Carcinosarcoma of the stomach: a case report and review of the literature. World J Gastroenterol. 2007; 13(41): 5533–5536.