open access

Vol 10, No 5 (2014)
Other materials agreed with the Editors
Published online: 2014-11-18
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The role of stereotactic radiotherapy in the treatment of oligometastases

Gregory M.M. Videtic
Onkol. Prak. Klin 2014;10(5):263-269.

open access

Vol 10, No 5 (2014)
Onkologia na świecie
Published online: 2014-11-18

Abstract

”Oligometastasis” describes a limited number of metastases arising typically from solid tumors whose behavior suggests an “intermediate” malignant state since it may potentially have a more favorable prognosis. Historically, selected patients with oligometastases often underwent surgical resection since an ecdotal evidence suggested it could improve progression-free or overall survival. No prospective randomized trial evidence to date supports survival benefits from surgery. Short courses of highly focused, very high dose radiotherapy (stereotactic radiosurgery; stereotactic body radiotherapy) have emerged as a surgical surrogate to manage oligometastates. Forsolitary brain metastases, randomized study evidence supports stereotactic radiosurgery as part of their management because of overall survival benefits. Modeled after stereotactic radiosurgery, stereotactic body radiotherapy for extracranial metastases is becoming increasingly common given its efficacy and low toxicity, is an active area of clinical research, and is the subject of this review.

Abstract

”Oligometastasis” describes a limited number of metastases arising typically from solid tumors whose behavior suggests an “intermediate” malignant state since it may potentially have a more favorable prognosis. Historically, selected patients with oligometastases often underwent surgical resection since an ecdotal evidence suggested it could improve progression-free or overall survival. No prospective randomized trial evidence to date supports survival benefits from surgery. Short courses of highly focused, very high dose radiotherapy (stereotactic radiosurgery; stereotactic body radiotherapy) have emerged as a surgical surrogate to manage oligometastates. Forsolitary brain metastases, randomized study evidence supports stereotactic radiosurgery as part of their management because of overall survival benefits. Modeled after stereotactic radiosurgery, stereotactic body radiotherapy for extracranial metastases is becoming increasingly common given its efficacy and low toxicity, is an active area of clinical research, and is the subject of this review.
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Keywords

cancer, oligometastases, surgery, stereotactic body radiotherapy, oncology

About this article
Title

The role of stereotactic radiotherapy in the treatment of oligometastases

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 5 (2014)

Article type

Other materials agreed with the Editors

Pages

263-269

Published online

2014-11-18

Bibliographic record

Onkol. Prak. Klin 2014;10(5):263-269.

Keywords

cancer
oligometastases
surgery
stereotactic body radiotherapy
oncology

Authors

Gregory M.M. Videtic

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