open access

Vol 10, No 2 (2014)
Review paper
Published online: 2014-05-14
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Adjuvant chemotherapy in patients with early breast cancer — the current state of knowledge

Katarzyna Pogoda, Izabela Lemańska, Anna Niwińska, Zbigniew I. Nowecki
Onkol. Prak. Klin 2014;10(2):89-102.

open access

Vol 10, No 2 (2014)
REVIEW ARTICLES
Published online: 2014-05-14

Abstract

Adjuvant chemotherapy is one of the elements used in combined treatment of patients with early breast cancer. The decision if chemotherapy should be given and the choice of regimen must be individualized depending on the nature of the tumor (stage, hormonal receptor and HER2 status, grade, Ki-67 expression) and patient’s characteristic (biological age, comorbidities) and the patient’s preference. A number of clinical trials evaluating the effectiveness of different regimens in adjuvant setting were performed. We discuss the results of the most important studies including their recently published updates which have a longer follow-up period. We present the current management of breast cancer patients receiving adjuvant therapy. We also discuss the issues requiring further research (e.g. the assessment of specific regimens’ efficacy depending on biological subtype of breast cancer).

Abstract

Adjuvant chemotherapy is one of the elements used in combined treatment of patients with early breast cancer. The decision if chemotherapy should be given and the choice of regimen must be individualized depending on the nature of the tumor (stage, hormonal receptor and HER2 status, grade, Ki-67 expression) and patient’s characteristic (biological age, comorbidities) and the patient’s preference. A number of clinical trials evaluating the effectiveness of different regimens in adjuvant setting were performed. We discuss the results of the most important studies including their recently published updates which have a longer follow-up period. We present the current management of breast cancer patients receiving adjuvant therapy. We also discuss the issues requiring further research (e.g. the assessment of specific regimens’ efficacy depending on biological subtype of breast cancer).

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Keywords

anthracyclines, adjuvant chemotherapy, early breast cancer, biological subtypes of breast cancer, older patients, taxanes

About this article
Title

Adjuvant chemotherapy in patients with early breast cancer — the current state of knowledge

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 2 (2014)

Article type

Review paper

Pages

89-102

Published online

2014-05-14

Bibliographic record

Onkol. Prak. Klin 2014;10(2):89-102.

Keywords

anthracyclines
adjuvant chemotherapy
early breast cancer
biological subtypes of breast cancer
older patients
taxanes

Authors

Katarzyna Pogoda
Izabela Lemańska
Anna Niwińska
Zbigniew I. Nowecki

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