open access

Vol 9, No 2 (2013)
Review paper
Published online: 2013-04-26
Get Citation

Non-small-cell lung cancer — maintenance treatment with pemetrexed

Maciej Krzakowski
Onkol. Prak. Klin 2013;9(2):55-59.

open access

Vol 9, No 2 (2013)
REVIEW ARTICLES
Published online: 2013-04-26

Abstract

Numerous randomised trials have investigated the value of maintenance treatment using of the same or different agents in patients with advanced non-small-cell lung cancer with objective response or stable disease following first-line platinum-based chemotherapy. The results of some studies have shown that maintenance chemotherapy may delay disease progression compared with placebo, but significant benefit in terms of overall survival prolongation has been demonstrated in case of two agents only (pemetrexed and erlotinib). Both agents are currently approved and may be used in clinical practice. However, some controversies still exist on the optimal use of maintenance treatment in clinical practice due to several unresolved issues to be answered in further studies and the use of maintenance therapy have to be recognised as an option in selected patients. This paper is aimed to discuss the results of clinical trials and details of maintenance treatment with pemetrexed.

Abstract

Numerous randomised trials have investigated the value of maintenance treatment using of the same or different agents in patients with advanced non-small-cell lung cancer with objective response or stable disease following first-line platinum-based chemotherapy. The results of some studies have shown that maintenance chemotherapy may delay disease progression compared with placebo, but significant benefit in terms of overall survival prolongation has been demonstrated in case of two agents only (pemetrexed and erlotinib). Both agents are currently approved and may be used in clinical practice. However, some controversies still exist on the optimal use of maintenance treatment in clinical practice due to several unresolved issues to be answered in further studies and the use of maintenance therapy have to be recognised as an option in selected patients. This paper is aimed to discuss the results of clinical trials and details of maintenance treatment with pemetrexed.

Get Citation

Keywords

non-small-cell lung cancer, chemotherapy, maintenance treatment

About this article
Title

Non-small-cell lung cancer — maintenance treatment with pemetrexed

Journal

Oncology in Clinical Practice

Issue

Vol 9, No 2 (2013)

Article type

Review paper

Pages

55-59

Published online

2013-04-26

Bibliographic record

Onkol. Prak. Klin 2013;9(2):55-59.

Keywords

non-small-cell lung cancer
chemotherapy
maintenance treatment

Authors

Maciej Krzakowski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl