open access

Vol 8, No 2 (2012)
Published online: 2012-06-27
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Treatment of breast cancer in elderly patients- comments to clinical case.

Iwona Głogowska
Onkol. Prak. Klin 2012;8(2):71-75.

open access

Vol 8, No 2 (2012)
Published online: 2012-06-27

Abstract

Approximately  40 – 60% of  patients  treated due to breast cancer are women in age 65 and older. There is no evidence based data on the treatment of this  age group because it was not enough represented in the controlled clinical trials with subsequent lack of generally accepted guidelines. The common occurrence of co morbidities may result in suboptimal treatment. The same radical surgery is advised for elderly patients as it is required for younger counterparts. Hormonal treatment has a priority as a systemic treatment of breast cancer in aged woman. Antracycline – based, multiagent chemotherapy increases risk of toxicity in this population.  If cytotoxic treatment is indicated, single agent chemotherapy,  administered on weekly basis, is the treatment of preference. There is a few data on the safety of targeted therapy in older women with  HER-2 positive breast cancer, although International Society of Geriatric Oncology (SIOG) recommends the same treatment as for younger women if there is no strong cardiologic contraindications for anti HER-2 therapy.  Treatment selection for elderly breast cancer women should include biological, clinical and social aspects and be as much cautious as possible.

Abstract

Approximately  40 – 60% of  patients  treated due to breast cancer are women in age 65 and older. There is no evidence based data on the treatment of this  age group because it was not enough represented in the controlled clinical trials with subsequent lack of generally accepted guidelines. The common occurrence of co morbidities may result in suboptimal treatment. The same radical surgery is advised for elderly patients as it is required for younger counterparts. Hormonal treatment has a priority as a systemic treatment of breast cancer in aged woman. Antracycline – based, multiagent chemotherapy increases risk of toxicity in this population.  If cytotoxic treatment is indicated, single agent chemotherapy,  administered on weekly basis, is the treatment of preference. There is a few data on the safety of targeted therapy in older women with  HER-2 positive breast cancer, although International Society of Geriatric Oncology (SIOG) recommends the same treatment as for younger women if there is no strong cardiologic contraindications for anti HER-2 therapy.  Treatment selection for elderly breast cancer women should include biological, clinical and social aspects and be as much cautious as possible.

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Keywords

breast cancer, elderly patients, systemic therapy, toxicity

About this article
Title

Treatment of breast cancer in elderly patients- comments to clinical case.

Journal

Oncology in Clinical Practice

Issue

Vol 8, No 2 (2012)

Pages

71-75

Published online

2012-06-27

Bibliographic record

Onkol. Prak. Klin 2012;8(2):71-75.

Keywords

breast cancer
elderly patients
systemic therapy
toxicity

Authors

Iwona Głogowska

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