Vol 22, No 1 (2019)
Clinical vignette
Published online: 2019-01-31

open access

Page views 759
Article views/downloads 756
Get Citation

Connect on Social Media

Connect on Social Media

Multiple photopenic vertebrae in the bone scintigraphy of a young man with Gorham disease: CT and MRI correlation

Ramin Sadeghi1, Sara Shakeri1, Toktam Massoudi1, Fatemeh Farahmandfar1, Farnaz Nesari Javan1
DOI: 10.5603/NMR.2019.0008
Pubmed: 31482543
Nucl. Med. Rev 2019;22(1):40-42.

Abstract

We report a rare pattern of extensive bone abnormalities on the Tc-99m MDP bone scintigraphy in a patient with Gorham disease. This rare condition is the result of vascular and lymphatic channel proliferation in bony structures which induce bone resorption. Our case is a 28-year-old man with a history of biopsy-proven soft tissue hemangioma in the left thigh, encountered with a recent diagnosis of multiple vertebral hemangiomata in the axial skeleton and progressive bony destructions in the pelvis on CT and MRI images, referred for bone scintigraphy. Multiple photopenic hemangiomata were noted on bone scan.

Article available in PDF format

View PDF Download PDF file

References

  1. Ruggieri P, Montalti M, Angelini A, et al. Gorham-Stout disease: the experience of the Rizzoli Institute and review of the literature. Skeletal Radiol. 2011; 40(11): 1391–1397.
  2. Patel DV. Gorham's disease or massive osteolysis. Clin Med Res. 2005; 3(2): 65–74.
  3. Nikolaou VS, Chytas D, Korres D, et al. Vanishing bone disease (Gorham-Stout syndrome): A review of a rare entity. World J Orthop. 2014; 5(5): 694–698.
  4. Flörchinger A, Böttger E, Claass-Böttger F, et al. [Gorham-Stout syndrome of the spine. Case report and review of the literature]. Rofo. 1998; 168(1): 68–76.
  5. Papadakis GZ, Millo C, Bagci U, et al. 18F-NaF and 18F-FDG PET/CT in Gorham-Stout Disease. Clin Nucl Med. 2016; 41(11): 884–885.
  6. Gorham LW, Stout AP. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); its relation to hemangiomatosis. J Bone Joint Surg Am. 1955; 37-A(5): 985–1004.
  7. Posadas MD, Viejo Stuart S, Romano O, et al. Gorham-Stout syndrome: a case report. Eur Rev Med Pharmacol Sci. 2014; 18(1 Suppl): 81–83.
  8. Yang RH, Chen PCH, Chang CP, et al. Gorham's disease: the disappearing bone. Clin Nucl Med. 2013; 38(5): 361–364.
  9. Brown RD, Studentsova Y, Margouleff D. Vanishing bone disease of the pelvis. Clin Nucl Med. 2004; 29(11): 709–711.
  10. Park SB, Choi JY, Kim SJ. Gorham-Stout Disease Affecting the Mandible: Bone Scintigraphy and Computed Tomography Findings. Clin Nucl Med. 2017; 42(10): 779–781.
  11. Mabille L, Berenger N, Laredo JD, et al. Vanishing vertebra. Clin Nucl Med. 1997; 22(1): 49–51.