open access
Free thyroxine in needle washout after fine needle aspiration biopsy of toxic thyroid nodules
open access
Abstract
The main diagnostic tool for toxic adenomas (TA) is radionuclide imaging indicated in patients with evidence of thyroid nodules in combination with thyrotoxic syndrome. Thyroid ultrasound and fine-needle aspiration biopsy (FNAB) are widely used for the valuation of thyroid masses. There is no literature data concerning the utility of FNAB and related tests for the diagnosis of hyperfunctioning thyroid nodules. The purpose of this study is to determine the levels of free thyroxine (FT4) in the needle washout after FNAB of hot thyroid nodules. The results of our study show that the FT4 levels in needle washout from TA were significantly higher than the surrounding parenchyma and correlated with the hormonal changes in patients with thyroid hyperfunctioning nodules. Further studies on a large number of patients are needed to refine the diagnostic value of this method and evaluate its importance in quantitative risk assessment of thyroid autonomy.
Abstract
The main diagnostic tool for toxic adenomas (TA) is radionuclide imaging indicated in patients with evidence of thyroid nodules in combination with thyrotoxic syndrome. Thyroid ultrasound and fine-needle aspiration biopsy (FNAB) are widely used for the valuation of thyroid masses. There is no literature data concerning the utility of FNAB and related tests for the diagnosis of hyperfunctioning thyroid nodules. The purpose of this study is to determine the levels of free thyroxine (FT4) in the needle washout after FNAB of hot thyroid nodules. The results of our study show that the FT4 levels in needle washout from TA were significantly higher than the surrounding parenchyma and correlated with the hormonal changes in patients with thyroid hyperfunctioning nodules. Further studies on a large number of patients are needed to refine the diagnostic value of this method and evaluate its importance in quantitative risk assessment of thyroid autonomy.
Keywords
fine-needle aspiration biopsy (FNAB), hot thyroid nodules — toxic adenoma (TA), thyroid radionuclide imaging
Title
Free thyroxine in needle washout after fine needle aspiration biopsy of toxic thyroid nodules
Journal
Issue
Article type
Research paper
Pages
18-21
Published online
2016-01-29
Page views
1184
Article views/downloads
1662
DOI
10.5603/NMR.2016.0004
Pubmed
Bibliographic record
Nucl. Med. Rev 2016;19(1):18-21.
Keywords
fine-needle aspiration biopsy (FNAB)
hot thyroid nodules — toxic adenoma (TA)
thyroid radionuclide imaging
Authors
Nikolai Raikov
Boyan Nonchev
Borislav Chaushev
Diyana Vjagova
Svetoslav Todorov
Yana Bocheva
Daniela Malceva
Snejinka Vicheva
Asyia Raikova
Antoaneta Argatska
Miroslav Raikov