open access
124I-MIBG: a new promising positron-emitting radiopharmaceutical for the evaluation of neuroblastoma
open access
Abstract
Neuroblastoma is the most common extra-cranial solid tumor in pediatric patients. Despite the established role of 123I-MIBG and 131I-MIBG scintigraphy in this tumor, only limited data are available regarding the use of 124I-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT). We present our preliminary experience with 124I-MIBG PET/CT: two pediatric patients affected by neuroblastoma, who underwent 124I-MIBG PET/CT for pre-therapy distribution evaluation and restaging purposes. We aimed to evaluate whether 124I-MIBG PET/CT can detect as many or more neuroblastoma lesions than 123I/131I-MIBG imaging. Our cases show promising results, although further validation and standardization of 124I-MIBG PET/CT are required.
Abstract
Neuroblastoma is the most common extra-cranial solid tumor in pediatric patients. Despite the established role of 123I-MIBG and 131I-MIBG scintigraphy in this tumor, only limited data are available regarding the use of 124I-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT). We present our preliminary experience with 124I-MIBG PET/CT: two pediatric patients affected by neuroblastoma, who underwent 124I-MIBG PET/CT for pre-therapy distribution evaluation and restaging purposes. We aimed to evaluate whether 124I-MIBG PET/CT can detect as many or more neuroblastoma lesions than 123I/131I-MIBG imaging. Our cases show promising results, although further validation and standardization of 124I-MIBG PET/CT are required.
Keywords
neuroblastoma, 124I-MIBG PET/CT, bone metastases, 123I-MIBG scan, radiometabolic therapy
Title
124I-MIBG: a new promising positron-emitting radiopharmaceutical for the evaluation of neuroblastoma
Journal
Issue
Article type
Case report
Pages
102-106
Published online
2015-07-31
Page views
2557
Article views/downloads
2907
DOI
10.5603/NMR.2015.0024
Pubmed
Bibliographic record
Nucl. Med. Rev 2015;18(2):102-106.
Keywords
neuroblastoma
124I-MIBG PET/CT
bone metastases
123I-MIBG scan
radiometabolic therapy
Authors
Angelina Cistaro
Natale Quartuccio
Federico Caobelli
Arnoldo Piccardo
Rosario Paratore
Pietro Coppolino
Alessandro Sperandeo
Gaspare Arnone
Umberto Ficola