open access

Vol 17, No 2 (2014)
Original articles
Published online: 2014-07-30
Submitted: 2014-03-24
Accepted: 2014-07-02
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Effect of furosemide administration before F-18 fluorodeoxyglucose positron emission tomography/computed tomography on urine radioactivity and detection of uterine cervical cancer

Andrea d'Amico, Izabela Gorczewska, Kamil Gorczewski, Maria Turska-d'Amico, Marco Di Pietro
DOI: 10.5603/NMR.2014.0022
·
Nucl. Med. Rev 2014;17(2):83-86.

open access

Vol 17, No 2 (2014)
Original articles
Published online: 2014-07-30
Submitted: 2014-03-24
Accepted: 2014-07-02

Abstract

BACKGROUND: In evaluating uterine cervical cancer with 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), there may be overlap between the FDG activity at tumor sites and nonspecific radioactivity in the urine. We evaluated the efficacy of furosemide premedication with routine hydration to obtain better contrast and less overlap between cervical cancer and the urinary bladder.

MATERIAL AND METHODS: We retrospectively evaluated 166 patients who had primary or relapsed cervical cancer and underwent FDG PET/CT scanning with (133 patients) or without (33 patients) furosemide premedication (10 mg intravenous, slowly injected 30 min before the scan). We calculated bladder and tumor maximum and median standardized uptake value (SUVmax and SUVmed), and overlap between tumor and urinary activity was detected visually.

RESULTS: Overlap between urinary and tumor radioactivity was observed in 8 of 133 scans (6%) in patients who receive furosemide and in 3 of 33 scans (9%) in patients who did not receive furosemide. The SUVmax and SUVmed for the bladder were significantly lower in patients who were pretreated with furosemide (SUVmax, 6.3; SUVmed, 4.6) than patients who were not pretreated with furosemide (SUVmax, 8.8 [P ≤ 0.008]; SUVmed, 6.5 [P ≤ 0.002]). The tumor SUVmax and SUVmed were similar between the patient groups.

CONCLUSION: Furosemide premedication before FDG PET/CT scanning may enable improved evaluation of activity and extension of cervical cancer.

Abstract

BACKGROUND: In evaluating uterine cervical cancer with 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), there may be overlap between the FDG activity at tumor sites and nonspecific radioactivity in the urine. We evaluated the efficacy of furosemide premedication with routine hydration to obtain better contrast and less overlap between cervical cancer and the urinary bladder.

MATERIAL AND METHODS: We retrospectively evaluated 166 patients who had primary or relapsed cervical cancer and underwent FDG PET/CT scanning with (133 patients) or without (33 patients) furosemide premedication (10 mg intravenous, slowly injected 30 min before the scan). We calculated bladder and tumor maximum and median standardized uptake value (SUVmax and SUVmed), and overlap between tumor and urinary activity was detected visually.

RESULTS: Overlap between urinary and tumor radioactivity was observed in 8 of 133 scans (6%) in patients who receive furosemide and in 3 of 33 scans (9%) in patients who did not receive furosemide. The SUVmax and SUVmed for the bladder were significantly lower in patients who were pretreated with furosemide (SUVmax, 6.3; SUVmed, 4.6) than patients who were not pretreated with furosemide (SUVmax, 8.8 [P ≤ 0.008]; SUVmed, 6.5 [P ≤ 0.002]). The tumor SUVmax and SUVmed were similar between the patient groups.

CONCLUSION: Furosemide premedication before FDG PET/CT scanning may enable improved evaluation of activity and extension of cervical cancer.
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Keywords

gynecologic oncology, cervix, imaging, diuretic, bladder

About this article
Title

Effect of furosemide administration before F-18 fluorodeoxyglucose positron emission tomography/computed tomography on urine radioactivity and detection of uterine cervical cancer

Journal

Nuclear Medicine Review

Issue

Vol 17, No 2 (2014)

Pages

83-86

Published online

2014-07-30

DOI

10.5603/NMR.2014.0022

Bibliographic record

Nucl. Med. Rev 2014;17(2):83-86.

Keywords

gynecologic oncology
cervix
imaging
diuretic
bladder

Authors

Andrea d'Amico
Izabela Gorczewska
Kamil Gorczewski
Maria Turska-d'Amico
Marco Di Pietro

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