open access

Vol 25, No 2 (2022)
Clinical vignette
Submitted: 2021-09-05
Accepted: 2022-04-01
Published online: 2022-06-09
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99mTc-Vitamin C SPECT/CT imaging in SARS-CoV-2 associated pneumonia

Haluk B. Sayman1, Kubra N. Toplutas1, James Tunick2, Omer Aras3
·
Pubmed: 35699590
·
Nucl. Med. Rev 2022;25(2):127-128.
Affiliations
  1. Cerrahpasa Medical Faculty, Department of Nuclear Medicine, Istanbul University-Cerrahpasa, Istanbul,Turkey
  2. The IMC Lab, New York, United States
  3. Departament of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States

open access

Vol 25, No 2 (2022)
Clinical vignette
Submitted: 2021-09-05
Accepted: 2022-04-01
Published online: 2022-06-09

Abstract

We present the first 99mTc-Vitamin C single-photon emission computed tomography/computed tomography (SPECT/CT) images obtained in patients with SARS-CoV-2 (COVID-19) infection. The CT portion of SPECT/CT images showed mostly peripheral patchy and ground-glass opacities in both lungs, which are consistent with a diagnosis of SARS-CoV-2–associated pneumonia in both patients. 99mTc-Vitamin C SPECT images showed increased tracer uptake corresponding to abnormal lung findings seen on CT in patient 1 who was newly diagnosed and treatment naïve. However, no abnormal uptake corresponding to lung CT findings was seen in patient 2 who received anti-SARS-CoV-2 treatment.

Abstract

We present the first 99mTc-Vitamin C single-photon emission computed tomography/computed tomography (SPECT/CT) images obtained in patients with SARS-CoV-2 (COVID-19) infection. The CT portion of SPECT/CT images showed mostly peripheral patchy and ground-glass opacities in both lungs, which are consistent with a diagnosis of SARS-CoV-2–associated pneumonia in both patients. 99mTc-Vitamin C SPECT images showed increased tracer uptake corresponding to abnormal lung findings seen on CT in patient 1 who was newly diagnosed and treatment naïve. However, no abnormal uptake corresponding to lung CT findings was seen in patient 2 who received anti-SARS-CoV-2 treatment.

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Keywords

99mTc-Vitamin C; SPECT/CT; SARS-Cov-2, pneumonia

About this article
Title

99mTc-Vitamin C SPECT/CT imaging in SARS-CoV-2 associated pneumonia

Journal

Nuclear Medicine Review

Issue

Vol 25, No 2 (2022)

Article type

Clinical vignette

Pages

127-128

Published online

2022-06-09

Page views

4226

Article views/downloads

435

DOI

10.5603/NMR.a2022.0026

Pubmed

35699590

Bibliographic record

Nucl. Med. Rev 2022;25(2):127-128.

Keywords

99mTc-Vitamin C
SPECT/CT
SARS-Cov-2
pneumonia

Authors

Haluk B. Sayman
Kubra N. Toplutas
James Tunick
Omer Aras

References (8)
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  2. Zhang J, Rao X, Li Y, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021; 11(1): 5.
  3. Albano D, Bertagna F, Bertoli M, et al. Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region. J Nucl Med. 2020; 61(5): 632–636.
  4. García Vicente AM, Soriano Castrejón Á. Incidental COVID-19 Pneumonia on 18F-Fluorocholine PET/CT. Clin Nucl Med. 2020; 45(8): e376–e377.
  5. Stasiak CE, Cardoso FR, de Almeida SA, et al. Incidental finding of COVID-19 infection after [Ga]Ga-PSMA-11 PET/CT imaging in a patient with prostate cancer. Eur J Nucl Med Mol Imaging. 2021; 48(2): 653–654.
  6. Morón S, González E, Rojas J. 68Ga-DOTANOC PET/CT With Lung Involvement in the Era of COVID-19 Pandemic. Clin Nucl Med. 2021; 46(2): 166–167.
  7. Zheng J, Liu Y. 99mTc-Leukocyte Scintigraphy Revealed Viral Pulmonary Infection in a COVID-19 Patient. Clin Nucl Med. 2020; 45(10): 821–823.
  8. Burger IA, Niemann T, Patriki D, et al. Lung perfusion [Tc]-MAA SPECT/CT to rule out pulmonary embolism in COVID-19 patients with contraindications for iodine contrast. Eur J Nucl Med Mol Imaging. 2020; 47(9): 2209–2210.

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