open access

Vol 23, No 2 (2020)
Original articles
Published online: 2020-07-31
Submitted: 2019-12-13
Accepted: 2020-04-22
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The impact of depression and anxiety in prognosis of patients undergoing myocardial perfusion imaging with 99mTc tetrofosmin SPECT for evaluation of possible myocardial ischemia

Andreas Fotopoulos, Petros Petrikis, Ioannis Iakovou, Athanasios Papadopoulos, Konstantinos Sakelariou, Evangelia Gkika, Lampros Lakkas, Christos Touzios, Konstantinos Pappas, Antonios Klaroudas, Argyrios Doumas, Chrissa Sioka
DOI: 10.5603/NMR.a2020.0014
·
Nucl. Med. Rev 2020;23(2):58-62.

open access

Vol 23, No 2 (2020)
Original articles
Published online: 2020-07-31
Submitted: 2019-12-13
Accepted: 2020-04-22

Abstract

Background: The goal of this study was to evaluate the prevalence of depression and anxiety in patients subjected to myocardial perfusion imaging (MPI) with 99mTc tetrofosmin stress-rest single-photon emission computer tomography (SPECT), and their impact on their cardiological events or disease. Material and Methods: Patients referred to the Nuclear Medicine Department for 99mTc tetrofosmin myocardial MPI-SPECT were asked to fulfill the Zung Self-Rating Depression Scale (ZDS) and Hamilton anxiety questionnaire (HAQ). Among 213 patients who completed the ZDS and HAQ, 80 patients (59 males and 21 females) were selected for this study because they had no known psychological disease, other disease that could influence psychological status, or use of narcotic drugs. Collected data from MPI and psychological status were subsequently analyzed. Results: Among all 80 patients, 52 patients (65%) had abnormal MPI of whom 28/52 (53.8%) exhibited either depression, anxiety or both, and 28 (35%) patients had normal MPI of whom 10/28 (35.7%) had abnormal psychological status. The higher number of patients with abnormal psychological status in association with abnormal MPI was noted predominantly in patients with previously established coronary artery disease. A correlation was also noted between obesity, cardiac heredity and depression or anxiety in patients with abnormal MPI. Conclusions: Patients that exhibit depression, anxiety, or both, have high rates of myocardial ischemia, and thus are at risk for subsequent cardiological events.

Abstract

Background: The goal of this study was to evaluate the prevalence of depression and anxiety in patients subjected to myocardial perfusion imaging (MPI) with 99mTc tetrofosmin stress-rest single-photon emission computer tomography (SPECT), and their impact on their cardiological events or disease. Material and Methods: Patients referred to the Nuclear Medicine Department for 99mTc tetrofosmin myocardial MPI-SPECT were asked to fulfill the Zung Self-Rating Depression Scale (ZDS) and Hamilton anxiety questionnaire (HAQ). Among 213 patients who completed the ZDS and HAQ, 80 patients (59 males and 21 females) were selected for this study because they had no known psychological disease, other disease that could influence psychological status, or use of narcotic drugs. Collected data from MPI and psychological status were subsequently analyzed. Results: Among all 80 patients, 52 patients (65%) had abnormal MPI of whom 28/52 (53.8%) exhibited either depression, anxiety or both, and 28 (35%) patients had normal MPI of whom 10/28 (35.7%) had abnormal psychological status. The higher number of patients with abnormal psychological status in association with abnormal MPI was noted predominantly in patients with previously established coronary artery disease. A correlation was also noted between obesity, cardiac heredity and depression or anxiety in patients with abnormal MPI. Conclusions: Patients that exhibit depression, anxiety, or both, have high rates of myocardial ischemia, and thus are at risk for subsequent cardiological events.

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Keywords

myocardial perfusion imaging; myocardial ischemia; depression; anxiety; psychological status; MPI; SPECT

About this article
Title

The impact of depression and anxiety in prognosis of patients undergoing myocardial perfusion imaging with 99mTc tetrofosmin SPECT for evaluation of possible myocardial ischemia

Journal

Nuclear Medicine Review

Issue

Vol 23, No 2 (2020)

Pages

58-62

Published online

2020-07-31

DOI

10.5603/NMR.a2020.0014

Bibliographic record

Nucl. Med. Rev 2020;23(2):58-62.

Keywords

myocardial perfusion imaging
myocardial ischemia
depression
anxiety
psychological status
MPI
SPECT

Authors

Andreas Fotopoulos
Petros Petrikis
Ioannis Iakovou
Athanasios Papadopoulos
Konstantinos Sakelariou
Evangelia Gkika
Lampros Lakkas
Christos Touzios
Konstantinos Pappas
Antonios Klaroudas
Argyrios Doumas
Chrissa Sioka

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