open access

Vol 20, No 2 (2017)
Letter to Editor
Published online: 2017-05-25
Submitted: 2017-04-12
Accepted: 2017-05-10
Get Citation

An easy way to increase confidence in beta-amyloid PET evaluation

Otakar Belohlavek, Monika Jaruskova
DOI: 10.5603/NMR.2017.0019
·
Pubmed: 30900240
·
Nucl. Med. Rev 2017;20(2):107-109.

open access

Vol 20, No 2 (2017)
Letter to Editor
Published online: 2017-05-25
Submitted: 2017-04-12
Accepted: 2017-05-10

Abstract

BACKGROUND: In patients with brain atrophy, it is not easy to distinguish pathologic uptake of flutemetamol (FMM) in the gray matter from nonspecific, physiologic uptake in the white matter. In this paper we suggest an easy image processing method.

MATERIAL AND METHODS: The proof-of-concept study involved three patients with mild cognitive impairment and different graphical findings at FMM-PET. Two-phase FMM-PET was acquired; the early phase represented the perfusion of gray matter, while the late phase depicted the white matter and beta-amyloid load in the gray matter. The border of the gray matter was easily extracted from the early-phase images using thresholding and the isocontour “Edges” color table. The late phase was registered with the edge images of the early phase and displayed using alpha-blending.

RESULTS: Early- and late-phase image fusion displayed with appropriate color tables is presented in three different cases to illustrate the added value of the suggested approach.

CONCLUSIONS: Composite late-phase images with enhanced gray matter borders strongly facilitate assessment of beta-amyloid presence in the gray matter. This is especially helpful in patients with brain atrophy.

Abstract

BACKGROUND: In patients with brain atrophy, it is not easy to distinguish pathologic uptake of flutemetamol (FMM) in the gray matter from nonspecific, physiologic uptake in the white matter. In this paper we suggest an easy image processing method.

MATERIAL AND METHODS: The proof-of-concept study involved three patients with mild cognitive impairment and different graphical findings at FMM-PET. Two-phase FMM-PET was acquired; the early phase represented the perfusion of gray matter, while the late phase depicted the white matter and beta-amyloid load in the gray matter. The border of the gray matter was easily extracted from the early-phase images using thresholding and the isocontour “Edges” color table. The late phase was registered with the edge images of the early phase and displayed using alpha-blending.

RESULTS: Early- and late-phase image fusion displayed with appropriate color tables is presented in three different cases to illustrate the added value of the suggested approach.

CONCLUSIONS: Composite late-phase images with enhanced gray matter borders strongly facilitate assessment of beta-amyloid presence in the gray matter. This is especially helpful in patients with brain atrophy.

Get Citation

Keywords

positron-emission tomography, amyloid, brain, dementia, atrophy, flutemetamol

About this article
Title

An easy way to increase confidence in beta-amyloid PET evaluation

Journal

Nuclear Medicine Review

Issue

Vol 20, No 2 (2017)

Pages

107-109

Published online

2017-05-25

DOI

10.5603/NMR.2017.0019

Pubmed

30900240

Bibliographic record

Nucl. Med. Rev 2017;20(2):107-109.

Keywords

positron-emission tomography
amyloid
brain
dementia
atrophy
flutemetamol

Authors

Otakar Belohlavek
Monika Jaruskova

References (4)
  1. Blomquist G, Engler H, Nordberg A, et al. Unidirectional influx and net accumulation of PIB. Open Neuroimag J. 2008; 2: 114–125.
  2. Hsiao IT, Huang CC, Hsieh CJ, et al. Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies. Eur J Nucl Med Mol Imaging. 2012; 39(4): 613–620.
  3. Lin KJ, Hsiao IT, Hsu JL, et al. Imaging characteristic of dual-phase (18)F-florbetapir (AV-45/Amyvid) PET for the concomitant detection of perfusion deficits and beta-amyloid deposition in Alzheimer's disease and mild cognitive impairment. Eur J Nucl Med Mol Imaging. 2016; 43(7): 1304–1314.
  4. Valentina G, Silvia M, Marco P. Dual-phase amyloid PET: hitting two birds with one stone. Eur J Nucl Med Mol Imaging. 2016; 43(7): 1300–1303.

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