open access

Vol 19, Supp. B (2016)
Case Report
Published online: 2016-10-14
Submitted: 2015-10-27
Accepted: 2016-06-15
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A rare case of medullary carcinoma thyroid metastasizing to bilateral breast parenchyma

Aamna Hassan, Maimoona Siddiqui, Sidra Jahangir
DOI: 10.5603/NMR.2016.0031
·
Pubmed: 27900756

open access

Vol 19, Supp. B (2016)
Case Report
Published online: 2016-10-14
Submitted: 2015-10-27
Accepted: 2016-06-15

Abstract

Medullary carcinoma of the thyroid (MTC) commonly spreads through the lymphatics to distant sites such as lung, liver and bone. Spread to the breast is rare. We report a case of metastatic MTC which progressed to develop nodal metastases to cer­vical and mediastinal regions, visceral metastases to the liver, lung and ultimately to bilateral breasts. Clinically it is important to distinguish metastatic breast lesions from primary breast cancer as each is managed differently. Both cytological and radio­logical investigations were done followed by excision biopsy. Histopathological examination of post excision breast specimen revealed metastatic medullary carcinoma, with positive immunohistochemical staining for calcitonin. A brief review of literature and differential diagnosis is also presented.

Abstract

Medullary carcinoma of the thyroid (MTC) commonly spreads through the lymphatics to distant sites such as lung, liver and bone. Spread to the breast is rare. We report a case of metastatic MTC which progressed to develop nodal metastases to cer­vical and mediastinal regions, visceral metastases to the liver, lung and ultimately to bilateral breasts. Clinically it is important to distinguish metastatic breast lesions from primary breast cancer as each is managed differently. Both cytological and radio­logical investigations were done followed by excision biopsy. Histopathological examination of post excision breast specimen revealed metastatic medullary carcinoma, with positive immunohistochemical staining for calcitonin. A brief review of literature and differential diagnosis is also presented.

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Keywords

medullary carcinoma, metastasis, breast nodules, HYNEC octreotide scan

About this article
Title

A rare case of medullary carcinoma thyroid metastasizing to bilateral breast parenchyma

Journal

Nuclear Medicine Review

Issue

Vol 19, Supp. B (2016)

Pages

17-19

Published online

2016-10-14

DOI

10.5603/NMR.2016.0031

Pubmed

27900756

Keywords

medullary carcinoma
metastasis
breast nodules
HYNEC octreotide scan

Authors

Aamna Hassan
Maimoona Siddiqui
Sidra Jahangir

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