open access

Vol 18, No 1 (2015)
Case Report
Published online: 2015-01-29
Submitted: 2014-02-04
Accepted: 2014-09-18
Get Citation

Diagnostic value of 18F-FDG-PET/CT for monitoring myelofibrosis after allogeneic stem cell transplantation

Thorsten Derlin, Guntram Büsche, Nicolaus Kröger
DOI: 10.5603/NMR.2015.0008
·
Pubmed: 25633515
·
Nucl. Med. Rev 2015;18(1):35-36.

open access

Vol 18, No 1 (2015)
Case Report
Published online: 2015-01-29
Submitted: 2014-02-04
Accepted: 2014-09-18

Abstract

Myelofibrosis is a rare hematopoietic stem cell neoplasm leading to marked bone marrow fibrosis and ineffective hematopoiesis. We report a case highlighting the potential role of 18F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for therapy monitoring. A 62-year-old man with myelofibrosis underwent FDG-PET/CT for evaluation of the extent of disease before and after allogeneic stem cell transplantation (SCT). PET after SCT demonstrated complete normalization of initially increased bone marrow tracer uptake, consistent with bone marrow biopsy showing complete remission. 18F-FDG-PET/CT may become a valuable diagnostic tool in myelofibrosis, enabling both sensitive initial staging and therapy monitoring.

Abstract

Myelofibrosis is a rare hematopoietic stem cell neoplasm leading to marked bone marrow fibrosis and ineffective hematopoiesis. We report a case highlighting the potential role of 18F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for therapy monitoring. A 62-year-old man with myelofibrosis underwent FDG-PET/CT for evaluation of the extent of disease before and after allogeneic stem cell transplantation (SCT). PET after SCT demonstrated complete normalization of initially increased bone marrow tracer uptake, consistent with bone marrow biopsy showing complete remission. 18F-FDG-PET/CT may become a valuable diagnostic tool in myelofibrosis, enabling both sensitive initial staging and therapy monitoring.

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Keywords

myelofibrosis, bone marrow, stem cell transplantation, therapy monitoring, FDG, PET/CT

About this article
Title

Diagnostic value of 18F-FDG-PET/CT for monitoring myelofibrosis after allogeneic stem cell transplantation

Journal

Nuclear Medicine Review

Issue

Vol 18, No 1 (2015)

Pages

35-36

Published online

2015-01-29

DOI

10.5603/NMR.2015.0008

Pubmed

25633515

Bibliographic record

Nucl. Med. Rev 2015;18(1):35-36.

Keywords

myelofibrosis
bone marrow
stem cell transplantation
therapy monitoring
FDG
PET/CT

Authors

Thorsten Derlin
Guntram Büsche
Nicolaus Kröger

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