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Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) — imaging manifestations of renal involvement
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Abstract
A 23-year-old lady presented with abdominal fullness and distension as well as large abdominal masses in physical exam. Upon ultrasonographic evaluation, two large space occupying lesions anterior to kidneys, with no clear distinction from renal tissue, as well as bilateral hydronephrosis were found. The findings were confirmed by MRI. Histopathological analysis of renal masses and lymph nodes showed proliferation of histiocytes mixed with occasional multinucleated giant cells, immunostaining of which was positive for S-100 and CD68. We present renal scintigraphy features of this rare case of renal sinus histiocytosis with massive intraabdominal lymphadenopathy (Rosai-Dorfman disease).
Abstract
A 23-year-old lady presented with abdominal fullness and distension as well as large abdominal masses in physical exam. Upon ultrasonographic evaluation, two large space occupying lesions anterior to kidneys, with no clear distinction from renal tissue, as well as bilateral hydronephrosis were found. The findings were confirmed by MRI. Histopathological analysis of renal masses and lymph nodes showed proliferation of histiocytes mixed with occasional multinucleated giant cells, immunostaining of which was positive for S-100 and CD68. We present renal scintigraphy features of this rare case of renal sinus histiocytosis with massive intraabdominal lymphadenopathy (Rosai-Dorfman disease).
Keywords
sinus histiocytosis, massive lymphadenopathy, Rosai-Dorfman disease, renal scintigraphy, 99mTc-DMSA, 99mTc-EC, magnetic resonance imaging
Title
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) — imaging manifestations of renal involvement
Journal
Issue
Article type
Case report
Pages
44-46
Published online
2014-03-03
Page views
1608
Article views/downloads
2120
DOI
10.5603/NMR.2014.0011
Bibliographic record
Nucl. Med. Rev 2014;17(1):44-46.
Keywords
sinus histiocytosis
massive lymphadenopathy
Rosai-Dorfman disease
renal scintigraphy
99mTc-DMSA
99mTc-EC
magnetic resonance imaging
Authors
Sina Izadyar
Farhad Samiei
Ali Gholamrezanezhad