open access

Vol 16, No 1 (2013)
Reviews
Published online: 2013-02-08
Submitted: 2013-02-08
Accepted: 2013-02-08
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Neurological applications for myocardial MIBG scintigraphy

Lucio Giuseppe Cascini, Vincenzo Cuccurullo, Antonio Restuccia, Oscar Tamburrini, Antonio Rotondo, Luigi Mansi
DOI: 10.5603/NMR.2013.0007
·
Nucl. Med. Rev 2013;16(1):35-41.

open access

Vol 16, No 1 (2013)
Reviews
Published online: 2013-02-08
Submitted: 2013-02-08
Accepted: 2013-02-08

Abstract

Signs or symptoms of impaired autonomic regulation of circulation
are typically present in patients affected by Parkinson’s
disease (PD), in agreement with the cardiac sympathetic
denervation discovered by Goldstein more than 15 yrs. ago.
In particular, the majority of PD patients have a diffuse left ventricular
myocardial sympathetic denervation, being a normal
neurological condition present only in a small number of affected
subjects. Actually MIBG cardiac imaging is a universally
accepted method to estimate cardiac sympathetic innervations.
This review covers the role of MIBG cardiac imaging in PD as well
as in other parkinsonisms, focusing the attention on technical
problems and pathophysiological premises for cardiac denervation.
In particular new emerging data support the role of MIBG as
biomarker of PD, also before motor symptoms became clinically
evident. Therefore the timing of cardiac noradrenergic denervation
in PD is a key issue and we want to update the analysis of
autonomic cardiovascular abnormalities studied with MIBG in
PD and related disorders.

Abstract

Signs or symptoms of impaired autonomic regulation of circulation
are typically present in patients affected by Parkinson’s
disease (PD), in agreement with the cardiac sympathetic
denervation discovered by Goldstein more than 15 yrs. ago.
In particular, the majority of PD patients have a diffuse left ventricular
myocardial sympathetic denervation, being a normal
neurological condition present only in a small number of affected
subjects. Actually MIBG cardiac imaging is a universally
accepted method to estimate cardiac sympathetic innervations.
This review covers the role of MIBG cardiac imaging in PD as well
as in other parkinsonisms, focusing the attention on technical
problems and pathophysiological premises for cardiac denervation.
In particular new emerging data support the role of MIBG as
biomarker of PD, also before motor symptoms became clinically
evident. Therefore the timing of cardiac noradrenergic denervation
in PD is a key issue and we want to update the analysis of
autonomic cardiovascular abnormalities studied with MIBG in
PD and related disorders.
Get Citation

Keywords

sympathetic innervation; Parkinson disease; parkinsonism; MIBG; myocardium

About this article
Title

Neurological applications for myocardial MIBG scintigraphy

Journal

Nuclear Medicine Review

Issue

Vol 16, No 1 (2013)

Pages

35-41

Published online

2013-02-08

DOI

10.5603/NMR.2013.0007

Bibliographic record

Nucl. Med. Rev 2013;16(1):35-41.

Keywords

sympathetic innervation
Parkinson disease
parkinsonism
MIBG
myocardium

Authors

Lucio Giuseppe Cascini
Vincenzo Cuccurullo
Antonio Restuccia
Oscar Tamburrini
Antonio Rotondo
Luigi Mansi

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