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Role of F18-FDG-PET/CT in restaging patients affected by renal carcinoma
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Abstract
cancers and the most common type of (90%) is renal cell carcinoma
Five-year survival rate in renal cancer patients is 68.4%.
AIM: The aim of our study was to establish the role of
F18-FDG-PET/CT in restaging patients with renal carcinoma who
underwent partial or radical nephrectomy. Secondary aim of the
study was to identify histological characteristics of the primary
tumour that may be responsible for the metabolic behaviour of
neoplastic lesions.
MATERIALS AND METHODS:We retrospectively evaluated
68 patients with renal carcinoma in whom F18-FDG-PET/CT
was performed.
RESULTS: Sensitivity, specificity, positive predictive value,
negative predictive value and accuracy of F18-FDG PET/CT were
82%, 100%, 100%, 66.7% and 86.8%, respectively.
CONCLUSIONS: The results of our study suggest that F18-FDG
PET/CT is characterised by high specificity and positive predictive
value and can be useful in restaging patients affected by renal carcinoma. However, due to low negative predictive value,
this method cannot be recommended for definitely ruling out
suspected disease relapse.
Abstract
cancers and the most common type of (90%) is renal cell carcinoma
Five-year survival rate in renal cancer patients is 68.4%.
AIM: The aim of our study was to establish the role of
F18-FDG-PET/CT in restaging patients with renal carcinoma who
underwent partial or radical nephrectomy. Secondary aim of the
study was to identify histological characteristics of the primary
tumour that may be responsible for the metabolic behaviour of
neoplastic lesions.
MATERIALS AND METHODS:We retrospectively evaluated
68 patients with renal carcinoma in whom F18-FDG-PET/CT
was performed.
RESULTS: Sensitivity, specificity, positive predictive value,
negative predictive value and accuracy of F18-FDG PET/CT were
82%, 100%, 100%, 66.7% and 86.8%, respectively.
CONCLUSIONS: The results of our study suggest that F18-FDG
PET/CT is characterised by high specificity and positive predictive
value and can be useful in restaging patients affected by renal carcinoma. However, due to low negative predictive value,
this method cannot be recommended for definitely ruling out
suspected disease relapse.
Keywords
PET/CT; F18-FDG; renal cell carcinoma
About this articleTitle
Role of F18-FDG-PET/CT in restaging patients affected by renal carcinoma
Journal
Issue
Pages
3-8
Published online
2013-02-08
DOI
10.5603/NMR.2013.0002
Bibliographic record
Nucl. Med. Rev 2013;16(1):3-8.
Keywords
PET/CT
F18-FDG
renal cell carcinoma
Authors
Francesco Bertagna
Federica Motta
Mattia Bertoli
Giovanni Bosio
Simona Fisogni
Regina Tardanico
Vittorio Ferrari
Alessandro Antonelli
Claudio Simeone
Sergio Cosciani Cunico
Raffaele Giubbini