open access

Vol 2, No 2 (1999)
Published online: 2000-02-25
Submitted: 2012-01-23
Get Citation

67Ga SPECT in detection of infection and inflammation

Jaroslaw B. Ćwikła, John R. Buscombe, Daksha S. Thakrar, Andy G. Irwin, Andrew J. W. Hilson
Nucl. Med. Rev 1999;2(2):69-73.

open access

Vol 2, No 2 (1999)
Published online: 2000-02-25
Submitted: 2012-01-23

Abstract


BACKGROUND: The aim of this study was to assess the value of 67Ga SPECT in detection and localisation of sources of infection/ inflammation.
MATERIALS AND METHODS: This study was performed on 24 patients (25 examinations) with suspected infection/inflammation. All patients underwent both planar and tomographic studies. There were 10 studies of abdomen and pelvis, 11 lower leg scans and 4 studies of upper chest and neck. We used a twohead gamma camera in each case. A planar whole body scan was performed with slow scan speed (10 cm/min), followed by a SPECT acquisition 48 hours after i.v. injection of 100-200 MBq 67Ga. Tomographic reconstruction was performed using a Ramp back-projection filter. These images were then smoothed using an automatically applied count optimised post-projection 3D Metz filter. Attenuation correction and scatter correction were not performed. Images were displayed as re-orientated transverse, coronal and sagittal slices. Planar and SPECT studies were assessed by two physicians trained in Nuclear Medicine, blinded to clinical details and compared with final pathological results. RESULTS: All planar and SPECT studies were of good quality. Overall diagnostic accuracy was as follows: sensitivity 100% specificity 67%, PPV 90% and NPV 100%. SPECT examination provided additional information about unexpected sources of confirmed infection on a site basis but did not find any additional patients which were not detected on planar examination. Localisation of sites of infection was more easily achieved with SPECT than planar imaging alone, especially when the transaxial slices were compared with CT or MRI.
CONCLUSIONS: We recommend 67Ga SPECT study as a tool to improve the accuracy of scintigraphy in detecting the number of sites of infection and their localisation.

Abstract


BACKGROUND: The aim of this study was to assess the value of 67Ga SPECT in detection and localisation of sources of infection/ inflammation.
MATERIALS AND METHODS: This study was performed on 24 patients (25 examinations) with suspected infection/inflammation. All patients underwent both planar and tomographic studies. There were 10 studies of abdomen and pelvis, 11 lower leg scans and 4 studies of upper chest and neck. We used a twohead gamma camera in each case. A planar whole body scan was performed with slow scan speed (10 cm/min), followed by a SPECT acquisition 48 hours after i.v. injection of 100-200 MBq 67Ga. Tomographic reconstruction was performed using a Ramp back-projection filter. These images were then smoothed using an automatically applied count optimised post-projection 3D Metz filter. Attenuation correction and scatter correction were not performed. Images were displayed as re-orientated transverse, coronal and sagittal slices. Planar and SPECT studies were assessed by two physicians trained in Nuclear Medicine, blinded to clinical details and compared with final pathological results. RESULTS: All planar and SPECT studies were of good quality. Overall diagnostic accuracy was as follows: sensitivity 100% specificity 67%, PPV 90% and NPV 100%. SPECT examination provided additional information about unexpected sources of confirmed infection on a site basis but did not find any additional patients which were not detected on planar examination. Localisation of sites of infection was more easily achieved with SPECT than planar imaging alone, especially when the transaxial slices were compared with CT or MRI.
CONCLUSIONS: We recommend 67Ga SPECT study as a tool to improve the accuracy of scintigraphy in detecting the number of sites of infection and their localisation.
Get Citation

Keywords

SPECT; 67Ga; infection and inflammation

About this article
Title

67Ga SPECT in detection of infection and inflammation

Journal

Nuclear Medicine Review

Issue

Vol 2, No 2 (1999)

Pages

69-73

Published online

2000-02-25

Bibliographic record

Nucl. Med. Rev 1999;2(2):69-73.

Keywords

SPECT
67Ga
infection and inflammation

Authors

Jaroslaw B. Ćwikła
John R. Buscombe
Daksha S. Thakrar
Andy G. Irwin
Andrew J. W. Hilson

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl