open access

Vol 3, No 1 (2000)
Published online: 2000-02-25
Submitted: 2012-01-23
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Technetium-99mTc-HMPAO brain SPECT in antiphospholipid syndrome - preliminary data

Grzegorz Romanowicz, Piotr Lass, Mirosława Koseda-Dragan, Roman Nowicki, Jarosława Krajka-Lauer
Nucl. Med. Rev 2000;3(1):17-20.

open access

Vol 3, No 1 (2000)
Published online: 2000-02-25
Submitted: 2012-01-23

Abstract

BACKGROUND: Antiphospholipid syndrome (APS) is defined as the presence of repeated episodes of arterial or venous thrombosis, recurrent spontaneous abortions and throbocytopenia in patients with elevated antiphospholipid antibodies. An important feature of APS are cerebrovascular disorders of thrombotic origin. The aim of the study was to assess cerebral blood flow changes utilising brain SPECT HMPAO scanning.
METHODS: Brain SPECT 99mTc-HMPAO scanning was performed in 20 patients with APS: 12 with systemic lupus erythematosus, 4 with Sneddon's syndrome, 2 with Sjögren's syndrome, 2 with primary APS. 30 healthy volunteers served as a control group.
RESULTS: 19 studies were abnormal, 1 normal. Abnormalities consisted of multifocal perfusion deficits and diffuse decrease of regional blood flow. The average number of focal perfusion deficits was 4.8 ± 1.7. In 7 patients diffuse hypoperfusion of frontal lobes was seen, in 1 patient additionally hypoperfusion of temporal and occipital lobes. There was a correlation between the number of focal perfusion deficits and cognitive impairment in this group of patients. Correlation between SPECT images and clinical data was moderate in cerebellar syndrome and paresis, weak in persistent headache and vertigo.
CONCLUSIONS: Those results indicate the high utility of CBF brain SPECT scanning in antiphospholipid syndrome.

Abstract

BACKGROUND: Antiphospholipid syndrome (APS) is defined as the presence of repeated episodes of arterial or venous thrombosis, recurrent spontaneous abortions and throbocytopenia in patients with elevated antiphospholipid antibodies. An important feature of APS are cerebrovascular disorders of thrombotic origin. The aim of the study was to assess cerebral blood flow changes utilising brain SPECT HMPAO scanning.
METHODS: Brain SPECT 99mTc-HMPAO scanning was performed in 20 patients with APS: 12 with systemic lupus erythematosus, 4 with Sneddon's syndrome, 2 with Sjögren's syndrome, 2 with primary APS. 30 healthy volunteers served as a control group.
RESULTS: 19 studies were abnormal, 1 normal. Abnormalities consisted of multifocal perfusion deficits and diffuse decrease of regional blood flow. The average number of focal perfusion deficits was 4.8 ± 1.7. In 7 patients diffuse hypoperfusion of frontal lobes was seen, in 1 patient additionally hypoperfusion of temporal and occipital lobes. There was a correlation between the number of focal perfusion deficits and cognitive impairment in this group of patients. Correlation between SPECT images and clinical data was moderate in cerebellar syndrome and paresis, weak in persistent headache and vertigo.
CONCLUSIONS: Those results indicate the high utility of CBF brain SPECT scanning in antiphospholipid syndrome.
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Keywords

antiphospholipid syndrome; cerebrovascular circulation; single photon emission computed tomography

About this article
Title

Technetium-99mTc-HMPAO brain SPECT in antiphospholipid syndrome - preliminary data

Journal

Nuclear Medicine Review

Issue

Vol 3, No 1 (2000)

Pages

17-20

Published online

2000-02-25

Bibliographic record

Nucl. Med. Rev 2000;3(1):17-20.

Keywords

antiphospholipid syndrome
cerebrovascular circulation
single photon emission computed tomography

Authors

Grzegorz Romanowicz
Piotr Lass
Mirosława Koseda-Dragan
Roman Nowicki
Jarosława Krajka-Lauer

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