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Technetium-99mTc-HMPAO brain SPECT in antiphospholipid syndrome - preliminary data
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Abstract
METHODS: Brain SPECT 99mTc-HMPAO scanning was performed in 20 patients with APS: 12 with systemic lupus erythematosus, 4 with Sneddon's syndrome, 2 with Sjögren's syndrome, 2 with primary APS. 30 healthy volunteers served as a control group.
RESULTS: 19 studies were abnormal, 1 normal. Abnormalities consisted of multifocal perfusion deficits and diffuse decrease of regional blood flow. The average number of focal perfusion deficits was 4.8 ± 1.7. In 7 patients diffuse hypoperfusion of frontal lobes was seen, in 1 patient additionally hypoperfusion of temporal and occipital lobes. There was a correlation between the number of focal perfusion deficits and cognitive impairment in this group of patients. Correlation between SPECT images and clinical data was moderate in cerebellar syndrome and paresis, weak in persistent headache and vertigo.
CONCLUSIONS: Those results indicate the high utility of CBF brain SPECT scanning in antiphospholipid syndrome.
Abstract
METHODS: Brain SPECT 99mTc-HMPAO scanning was performed in 20 patients with APS: 12 with systemic lupus erythematosus, 4 with Sneddon's syndrome, 2 with Sjögren's syndrome, 2 with primary APS. 30 healthy volunteers served as a control group.
RESULTS: 19 studies were abnormal, 1 normal. Abnormalities consisted of multifocal perfusion deficits and diffuse decrease of regional blood flow. The average number of focal perfusion deficits was 4.8 ± 1.7. In 7 patients diffuse hypoperfusion of frontal lobes was seen, in 1 patient additionally hypoperfusion of temporal and occipital lobes. There was a correlation between the number of focal perfusion deficits and cognitive impairment in this group of patients. Correlation between SPECT images and clinical data was moderate in cerebellar syndrome and paresis, weak in persistent headache and vertigo.
CONCLUSIONS: Those results indicate the high utility of CBF brain SPECT scanning in antiphospholipid syndrome.
Keywords
antiphospholipid syndrome; cerebrovascular circulation; single photon emission computed tomography
Title
Technetium-99mTc-HMPAO brain SPECT in antiphospholipid syndrome - preliminary data
Journal
Issue
Pages
17-20
Published online
2000-02-25
Page views
668
Article views/downloads
1279
Bibliographic record
Nucl. Med. Rev 2000;3(1):17-20.
Keywords
antiphospholipid syndrome
cerebrovascular circulation
single photon emission computed tomography
Authors
Grzegorz Romanowicz
Piotr Lass
Mirosława Koseda-Dragan
Roman Nowicki
Jarosława Krajka-Lauer