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99mTc-HEPIDA plasma clearance as a diagnostic tool. Total plasma v. specific hepatic clearance
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Abstract
MATERIAL AND METHODS: To this aim total plasma clearance of the compound and urinary part were determined by the methods employed here in 117 patients and in 16 healthy volunteers. The pure hepatic clearance was calculated as the difference between total plasma and the urinary clearance of 99mTc-HEPIDA.
RESULTS: The urinary clearance in patients amounted from 2.6 to 78% of total clearance; in the healthy volunteers the corresponding range was from 8.6 to 28%. Pronounced spread of the urinary clearance (coefficient of variation = 35%) and lack of correlation between the urinary and total clearance make it necessary to take account of urinary elimination in each patient in whom reasonably accurate assessment of hepatic clearance is required.
CONCLUSION: Further studies on the diagnostic efficacy of pure hepatic clearance and its change with age in healthy patients appear necessary.
Abstract
MATERIAL AND METHODS: To this aim total plasma clearance of the compound and urinary part were determined by the methods employed here in 117 patients and in 16 healthy volunteers. The pure hepatic clearance was calculated as the difference between total plasma and the urinary clearance of 99mTc-HEPIDA.
RESULTS: The urinary clearance in patients amounted from 2.6 to 78% of total clearance; in the healthy volunteers the corresponding range was from 8.6 to 28%. Pronounced spread of the urinary clearance (coefficient of variation = 35%) and lack of correlation between the urinary and total clearance make it necessary to take account of urinary elimination in each patient in whom reasonably accurate assessment of hepatic clearance is required.
CONCLUSION: Further studies on the diagnostic efficacy of pure hepatic clearance and its change with age in healthy patients appear necessary.
Keywords
99mTc-HEPIDA: total plasma clearance; 99mTc-HEPIDA hepatic and urinary clearance
Title
99mTc-HEPIDA plasma clearance as a diagnostic tool. Total plasma v. specific hepatic clearance
Journal
Issue
Pages
35-38
Published online
2000-05-25
Page views
1001
Article views/downloads
1123
Bibliographic record
Nucl. Med. Rev 2001;4(1):35-38.
Keywords
99mTc-HEPIDA: total plasma clearance
99mTc-HEPIDA hepatic and urinary clearance
Authors
Izabela Frieske
Jolanta Białkowska-Warzecha
Julian Liniecki
Jan Kuydowicz
Jacek Kuśmierek
Marian J. Surma