open access

Vol 4, No 2 (2001)
Published online: 2001-07-23
Submitted: 2012-01-23
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The accuracy of myocardial perfusion SPECT imaging in the evaluation of coronary artery disease in women and men

Milan Kaminek, Miroslav Myslivecek, Vaclav Huśak, Pavel Koranda, Marcela Śkvarilova, Jiri Ostransky, Otto Lang
Nucl. Med. Rev 2001;4(2):69-72.

open access

Vol 4, No 2 (2001)
Published online: 2001-07-23
Submitted: 2012-01-23

Abstract


BACKGROUND: The purpose of this study is to compare sensitivity, specificity and accuracy of myocardial perfusion SPECT for the detection of coronary artery disease (CAD) in women and men.
MATERIAL AND METHODS: 588 patients (455 males and 133 females, 273 after a previous myocardial infarction) underwent stress myocardial perfusion SPECT. The accuracy of myocardial perfusion SPECT was proved by coronary angiography (stenosis > 50% was considered as a CAD).
RESULTS: The sensitivity of SPECT was slightly higher, but statistically not significant, in men than in women (94% versus 91%, p > 0.05). The specificity was higher in women than in men (93% versus 82%), but this difference was not statistically significant either (p > 0.05). The accuracy of SPECT was the same for both sexes (92%). In angiographically verified group of patients the selection bias was obvious - patients with CAD dominated (74%) and the fraction of patients with CAD in men's group (83%) was significantly higher than in women's group (50%), p < 0.05.
CONCLUSIONS: No significant difference was revealed in the accuracy of myocardial perfusion SPECT in men and women. Our results are in accordance with the prevailing opinion in literature that discovered differences in sensitivity, specificity and diagnostic accuracy are usually not statistically significant or that they can be explained by the selection bias of patients in angiographically verified groups (significantly higher fraction of patients with CAD in men's group).

Abstract


BACKGROUND: The purpose of this study is to compare sensitivity, specificity and accuracy of myocardial perfusion SPECT for the detection of coronary artery disease (CAD) in women and men.
MATERIAL AND METHODS: 588 patients (455 males and 133 females, 273 after a previous myocardial infarction) underwent stress myocardial perfusion SPECT. The accuracy of myocardial perfusion SPECT was proved by coronary angiography (stenosis > 50% was considered as a CAD).
RESULTS: The sensitivity of SPECT was slightly higher, but statistically not significant, in men than in women (94% versus 91%, p > 0.05). The specificity was higher in women than in men (93% versus 82%), but this difference was not statistically significant either (p > 0.05). The accuracy of SPECT was the same for both sexes (92%). In angiographically verified group of patients the selection bias was obvious - patients with CAD dominated (74%) and the fraction of patients with CAD in men's group (83%) was significantly higher than in women's group (50%), p < 0.05.
CONCLUSIONS: No significant difference was revealed in the accuracy of myocardial perfusion SPECT in men and women. Our results are in accordance with the prevailing opinion in literature that discovered differences in sensitivity, specificity and diagnostic accuracy are usually not statistically significant or that they can be explained by the selection bias of patients in angiographically verified groups (significantly higher fraction of patients with CAD in men's group).
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Keywords

SPECT; myocardial perfusion; coronary artery disease; men and women

About this article
Title

The accuracy of myocardial perfusion SPECT imaging in the evaluation of coronary artery disease in women and men

Journal

Nuclear Medicine Review

Issue

Vol 4, No 2 (2001)

Pages

69-72

Published online

2001-07-23

Bibliographic record

Nucl. Med. Rev 2001;4(2):69-72.

Keywords

SPECT
myocardial perfusion
coronary artery disease
men and women

Authors

Milan Kaminek
Miroslav Myslivecek
Vaclav Huśak
Pavel Koranda
Marcela Śkvarilova
Jiri Ostransky
Otto Lang

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