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Alteration of 99mTc-DMSA biodistribution in glomerulonephritis
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Abstract
MATERIAL AND METHODS: Sixty-seven patients involved in this study were classified into two groups according to 99mTc-DTPA clearance and serum creatinine values: the 1st group consisted of 42 patients without renal failure while the 2nd group included 25 patients with renal failure. 99mTc-DMSA biodistribution was determined by measuring kidney, blood and urine activity at 2 h and 4 h.
RESULTS: The results, compared with those of 23 healthy volunteers, indicated the quantitative alteration of 99mTc-DMSA distribution in both glomerulonephritis patient groups. In reference to the control mean values of 2 h and 4 h, in patients without renal failure, kidney activity was found decreased to 52% and 57%, while the blood activity increase of 37% and 44% was recorded together with the urine activity increase of 38% and 23%. In patients with renal failure the alterations of renal and blood activity were more remarkable, but the urine loss was found to be unchanged.
CONCLUSIONS: It is suggested that these biodistribution changes originate mainly from tubular impairment. However, in glomerulonephritis patients, altered glomerular filtration might considerably affect biodistribution of this radiopharmaceutical and limits its suitability for precise quantitative estimation of renal function.
Abstract
MATERIAL AND METHODS: Sixty-seven patients involved in this study were classified into two groups according to 99mTc-DTPA clearance and serum creatinine values: the 1st group consisted of 42 patients without renal failure while the 2nd group included 25 patients with renal failure. 99mTc-DMSA biodistribution was determined by measuring kidney, blood and urine activity at 2 h and 4 h.
RESULTS: The results, compared with those of 23 healthy volunteers, indicated the quantitative alteration of 99mTc-DMSA distribution in both glomerulonephritis patient groups. In reference to the control mean values of 2 h and 4 h, in patients without renal failure, kidney activity was found decreased to 52% and 57%, while the blood activity increase of 37% and 44% was recorded together with the urine activity increase of 38% and 23%. In patients with renal failure the alterations of renal and blood activity were more remarkable, but the urine loss was found to be unchanged.
CONCLUSIONS: It is suggested that these biodistribution changes originate mainly from tubular impairment. However, in glomerulonephritis patients, altered glomerular filtration might considerably affect biodistribution of this radiopharmaceutical and limits its suitability for precise quantitative estimation of renal function.
Keywords
99mTc-DMSA; kidney activity; blood activity; urine activity; glomerulonephritis
About this articleTitle
Alteration of 99mTc-DMSA biodistribution in glomerulonephritis
Journal
Issue
Pages
15-19
Published online
2002-01-17
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737
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2018
Bibliographic record
Nucl. Med. Rev 2002;5(1):15-19.
Keywords
99mTc-DMSA
kidney activity
blood activity
urine activity
glomerulonephritis
Authors
Milena Rajić
Mamcilo Bogicevic
Slobodan Antic
Branka Mitic
Marina Avramovic
Slobodan Ilic
Marina Vlajkovic
Marina Mitic-Zlatovic
Vladislav Stefanovic
