open access

Vol 5, No 2 (2002)
Short communications
Published online: 2002-06-07
Submitted: 2012-01-23
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Comparison of peritumoral and subareolar injection of Tc99m sulphur colloid and blue-dye for detection of the sentinel lymph node in breast cancer

Tomasz Jastrzębski, Andrzej Kopacz, Piotr Lass
Nucl. Med. Rev 2002;5(2):159-161.

open access

Vol 5, No 2 (2002)
Short communications
Published online: 2002-06-07
Submitted: 2012-01-23

Abstract

BACKGROUND: The new trend in diagnosis of the lymph node is sentinel node biopsy. This method has become increasingly accepted as a minimally invasive alternative to routine axillary dissection. Although the results of numerous studies have shown that sentinel node biopsy can accurately determine the axillary nodal status, the identification rates and false-negative rates have been variable. The sentinel lymph node is defined as the first node in the lymphatic basin that receives the primary lymphatic flow.
MATERIAL AND METHODS: Between September 1998 and August 2002 123 patients with primary operative breast cancer without clinical palpable axillary lymph nodes were enrolled in the study. There were two groups of patients according to sentinel node identification technique: 51 patients (Group I) received parenchymal, peritumoral injection of 1.0 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and single intradermal injection of blue-dye over the tumour. The next 72 patients (Group II) received intradermal, periareolar one-site injection of 0.5 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and blue-dye.
RESULTS: Sentinel lymph node was found in 41 (80.4%) cases in Group I and in 67 (93.0%) cases in Group II (p = 0.028). The localisation of the axillary lymph node as a "hot spot" visualised by lymphoscintigraphy was successful in 39/51 (76.5%) cases in Group I and 67/72 (93.0%) in Group II, p = 0.004). In both groups the success of sentinel node identification in the axillary region by lymphoscintigraphy was connected with sentinel lymph node finding during surgery (Group I: p < 0.001, Group II: p < 0.001).
CONCLUSIONS: This study shows that intradermal, periareolar one-site injection of Tc99m-radiolabelled sulphur colloid and bluedye is superior to peritumoral 4-sites injections Tc99m-radiolabelled sulphur colloid and single intradermal injection of bluedye over the tumour in sentinel lymph node identification.

Abstract

BACKGROUND: The new trend in diagnosis of the lymph node is sentinel node biopsy. This method has become increasingly accepted as a minimally invasive alternative to routine axillary dissection. Although the results of numerous studies have shown that sentinel node biopsy can accurately determine the axillary nodal status, the identification rates and false-negative rates have been variable. The sentinel lymph node is defined as the first node in the lymphatic basin that receives the primary lymphatic flow.
MATERIAL AND METHODS: Between September 1998 and August 2002 123 patients with primary operative breast cancer without clinical palpable axillary lymph nodes were enrolled in the study. There were two groups of patients according to sentinel node identification technique: 51 patients (Group I) received parenchymal, peritumoral injection of 1.0 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and single intradermal injection of blue-dye over the tumour. The next 72 patients (Group II) received intradermal, periareolar one-site injection of 0.5 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and blue-dye.
RESULTS: Sentinel lymph node was found in 41 (80.4%) cases in Group I and in 67 (93.0%) cases in Group II (p = 0.028). The localisation of the axillary lymph node as a "hot spot" visualised by lymphoscintigraphy was successful in 39/51 (76.5%) cases in Group I and 67/72 (93.0%) in Group II, p = 0.004). In both groups the success of sentinel node identification in the axillary region by lymphoscintigraphy was connected with sentinel lymph node finding during surgery (Group I: p < 0.001, Group II: p < 0.001).
CONCLUSIONS: This study shows that intradermal, periareolar one-site injection of Tc99m-radiolabelled sulphur colloid and bluedye is superior to peritumoral 4-sites injections Tc99m-radiolabelled sulphur colloid and single intradermal injection of bluedye over the tumour in sentinel lymph node identification.
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Keywords

sentinel node; breast cancer; lymphoscintigraphy

About this article
Title

Comparison of peritumoral and subareolar injection of Tc99m sulphur colloid and blue-dye for detection of the sentinel lymph node in breast cancer

Journal

Nuclear Medicine Review

Issue

Vol 5, No 2 (2002)

Pages

159-161

Published online

2002-06-07

Bibliographic record

Nucl. Med. Rev 2002;5(2):159-161.

Keywords

sentinel node
breast cancer
lymphoscintigraphy

Authors

Tomasz Jastrzębski
Andrzej Kopacz
Piotr Lass

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