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Comparison of peritumoral and subareolar injection of Tc99m sulphur colloid and blue-dye for detection of the sentinel lymph node in breast cancer
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Abstract
MATERIAL AND METHODS: Between September 1998 and August 2002 123 patients with primary operative breast cancer without clinical palpable axillary lymph nodes were enrolled in the study. There were two groups of patients according to sentinel node identification technique: 51 patients (Group I) received parenchymal, peritumoral injection of 1.0 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and single intradermal injection of blue-dye over the tumour. The next 72 patients (Group II) received intradermal, periareolar one-site injection of 0.5 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and blue-dye.
RESULTS: Sentinel lymph node was found in 41 (80.4%) cases in Group I and in 67 (93.0%) cases in Group II (p = 0.028). The localisation of the axillary lymph node as a "hot spot" visualised by lymphoscintigraphy was successful in 39/51 (76.5%) cases in Group I and 67/72 (93.0%) in Group II, p = 0.004). In both groups the success of sentinel node identification in the axillary region by lymphoscintigraphy was connected with sentinel lymph node finding during surgery (Group I: p < 0.001, Group II: p < 0.001).
CONCLUSIONS: This study shows that intradermal, periareolar one-site injection of Tc99m-radiolabelled sulphur colloid and bluedye is superior to peritumoral 4-sites injections Tc99m-radiolabelled sulphur colloid and single intradermal injection of bluedye over the tumour in sentinel lymph node identification.
Abstract
MATERIAL AND METHODS: Between September 1998 and August 2002 123 patients with primary operative breast cancer without clinical palpable axillary lymph nodes were enrolled in the study. There were two groups of patients according to sentinel node identification technique: 51 patients (Group I) received parenchymal, peritumoral injection of 1.0 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and single intradermal injection of blue-dye over the tumour. The next 72 patients (Group II) received intradermal, periareolar one-site injection of 0.5 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and blue-dye.
RESULTS: Sentinel lymph node was found in 41 (80.4%) cases in Group I and in 67 (93.0%) cases in Group II (p = 0.028). The localisation of the axillary lymph node as a "hot spot" visualised by lymphoscintigraphy was successful in 39/51 (76.5%) cases in Group I and 67/72 (93.0%) in Group II, p = 0.004). In both groups the success of sentinel node identification in the axillary region by lymphoscintigraphy was connected with sentinel lymph node finding during surgery (Group I: p < 0.001, Group II: p < 0.001).
CONCLUSIONS: This study shows that intradermal, periareolar one-site injection of Tc99m-radiolabelled sulphur colloid and bluedye is superior to peritumoral 4-sites injections Tc99m-radiolabelled sulphur colloid and single intradermal injection of bluedye over the tumour in sentinel lymph node identification.
Keywords
sentinel node; breast cancer; lymphoscintigraphy
Title
Comparison of peritumoral and subareolar injection of Tc99m sulphur colloid and blue-dye for detection of the sentinel lymph node in breast cancer
Journal
Issue
Article type
Brief communication
Pages
159-161
Published online
2002-06-07
Page views
806
Article views/downloads
1174
Bibliographic record
Nucl. Med. Rev 2002;5(2):159-161.
Keywords
sentinel node
breast cancer
lymphoscintigraphy
Authors
Tomasz Jastrzębski
Andrzej Kopacz
Piotr Lass