open access

Vol 5, No 2 (2002)
Published online: 2002-06-07
Submitted: 2012-01-23
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Technetium-99m MIBI imaging in diagnosis of pelvic and abdominal masses in patients with suspected gynaecological malignancy

Leszek Królicki, Jarosław Ćwikła, Agnieszka Timorek, Małgorzata Ruszczyńska, Jerzy Stelmachow, Włodzimierz Sawicki, Agnieszka D. Kolasińska, Jolanta Kupryjańczyk, Gidon Lieberman, John R. Buscombe
Nucl. Med. Rev 2002;5(2):131-137.

open access

Vol 5, No 2 (2002)
Published online: 2002-06-07
Submitted: 2012-01-23

Abstract

BACKGROUND: The aim of this study was to determine the diagnostic value of 99mTc MIBI planar dynamic scintigraphy in the diagnosis of gynaecological malignancies and to determine if it has a greater diagnostic accuracy than conventional ultrasound technique (US).
MATERIAL AND METHODS: A prospective trial was performed to assess the accuracy of 99mTc MIBI scintigraphy and ultrasound in 93 female patients (mean age 50, SD 16; range 17-82 years). Three readers assessed all the imaging independently and this was compared with histological examination in 89 cases and by clinical follow-up and correlative imaging for a minimum of 6 months in 4 patients.
RESULTS: There were 37 patients with cancer of gynaecological origin. There were in addition 56 benign lesions within the pelvis. 99mTc MIBI identified correctly 29 of the 37 malignant tumours localised within the pelvis and also correctly identified 21 of 23 metastases within the abdomen. Conventional US identified correctly 35 of the 37 tumours in the pelvis and 16 sites of metastases within the abdomen. The sensitivity and specificity of tumour detection within the pelvis for 99mTc MIBI were as follows: 78% and 70%; and for metastases within the abdomen 91% and 90%. The results of ultrasound for tumour detection within the pelvis: the sensitivity and specificity were 95% and 79% and for abdominal metastases 70% and 97%. Analysis of the index area under a receiver operator haracteristic (ROC) curve in scintigraphy did not show a significant difference between both techniques in the diagnosis of pelvic lesions. There was however a significant increase in the sensitivity of scintigraphy 99mTc MIBI over US in metastases detection within the abdomen.
CONCLUSIONS: 99mTc MIBI cannot be recommended for the imaging of pelvic cancer alone, but it may be helpful in the identification of intra-abdominal spread of ovarian carcinoma and appears to offer significant advantages over ultrasound.

Abstract

BACKGROUND: The aim of this study was to determine the diagnostic value of 99mTc MIBI planar dynamic scintigraphy in the diagnosis of gynaecological malignancies and to determine if it has a greater diagnostic accuracy than conventional ultrasound technique (US).
MATERIAL AND METHODS: A prospective trial was performed to assess the accuracy of 99mTc MIBI scintigraphy and ultrasound in 93 female patients (mean age 50, SD 16; range 17-82 years). Three readers assessed all the imaging independently and this was compared with histological examination in 89 cases and by clinical follow-up and correlative imaging for a minimum of 6 months in 4 patients.
RESULTS: There were 37 patients with cancer of gynaecological origin. There were in addition 56 benign lesions within the pelvis. 99mTc MIBI identified correctly 29 of the 37 malignant tumours localised within the pelvis and also correctly identified 21 of 23 metastases within the abdomen. Conventional US identified correctly 35 of the 37 tumours in the pelvis and 16 sites of metastases within the abdomen. The sensitivity and specificity of tumour detection within the pelvis for 99mTc MIBI were as follows: 78% and 70%; and for metastases within the abdomen 91% and 90%. The results of ultrasound for tumour detection within the pelvis: the sensitivity and specificity were 95% and 79% and for abdominal metastases 70% and 97%. Analysis of the index area under a receiver operator haracteristic (ROC) curve in scintigraphy did not show a significant difference between both techniques in the diagnosis of pelvic lesions. There was however a significant increase in the sensitivity of scintigraphy 99mTc MIBI over US in metastases detection within the abdomen.
CONCLUSIONS: 99mTc MIBI cannot be recommended for the imaging of pelvic cancer alone, but it may be helpful in the identification of intra-abdominal spread of ovarian carcinoma and appears to offer significant advantages over ultrasound.
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Keywords

gynaecological malignancies; 99mTc MIBI; dynamic scintigraphy

About this article
Title

Technetium-99m MIBI imaging in diagnosis of pelvic and abdominal masses in patients with suspected gynaecological malignancy

Journal

Nuclear Medicine Review

Issue

Vol 5, No 2 (2002)

Pages

131-137

Published online

2002-06-07

Bibliographic record

Nucl. Med. Rev 2002;5(2):131-137.

Keywords

gynaecological malignancies
99mTc MIBI
dynamic scintigraphy

Authors

Leszek Królicki
Jarosław Ćwikła
Agnieszka Timorek
Małgorzata Ruszczyńska
Jerzy Stelmachow
Włodzimierz Sawicki
Agnieszka D. Kolasińska
Jolanta Kupryjańczyk
Gidon Lieberman
John R. Buscombe

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