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Clinical significance of optimal red cell mass and plasma volume estimation methods
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Abstract
MATERIAL AND METHODS: In 120/280 patients with polycythaemia rubra vera, subjected to RCM&PV determination with autologous erythrocytes in vitro labelled with 51Cr-sodium chromate, optimal volumes were determined using:
1. traditional ml/kg of:
- the real body weight method (ml/kg RBW);
- the optimal body weight method (ml/kg OBW).
2. the body weight, height, and sex based method (Retzlaff's tables),
3. the method recommended by the International Council for Standardization in Haematology (ICSH), based on body surface area.
RESULTS: Different interpretation of the same results of 120 RCM&PV measurements was registered in 48/120 patients (40%). The greatest disagreement existed between ml/kg RBW and ml/kg OBW methods (in 39/120 subjects, 32.5%). In underweight patients the ml/kg RBW method, and in overweight patients the ml/kg OBW method, offered better agreement with ICSH&Retzlaff's methods. The ml/kg RBW method disagreed with ICSH&Retzlaff's methods and ml/kg OBW in 25% and 19.2% of patients respectively. ICSH and Retzlaff's methods disagreed in 10/120 patients (8.3%). The ICSH method yielded significantly lower optimal volumes than Retzlaff's.
CONCLUSION: Three methods for optimal RCM&PV estimation lead to different interpretations of the same results of RCM&PV measurements with 51Cr-erythrocytes in 40% of patients. Two ml/kg body weight methods show greater disagreement in comparison with ICSH and Retzlaff's methods, which differ significantly. The ICSH method yields lower optimal values compared to Retzlaff's.
Abstract
MATERIAL AND METHODS: In 120/280 patients with polycythaemia rubra vera, subjected to RCM&PV determination with autologous erythrocytes in vitro labelled with 51Cr-sodium chromate, optimal volumes were determined using:
1. traditional ml/kg of:
- the real body weight method (ml/kg RBW);
- the optimal body weight method (ml/kg OBW).
2. the body weight, height, and sex based method (Retzlaff's tables),
3. the method recommended by the International Council for Standardization in Haematology (ICSH), based on body surface area.
RESULTS: Different interpretation of the same results of 120 RCM&PV measurements was registered in 48/120 patients (40%). The greatest disagreement existed between ml/kg RBW and ml/kg OBW methods (in 39/120 subjects, 32.5%). In underweight patients the ml/kg RBW method, and in overweight patients the ml/kg OBW method, offered better agreement with ICSH&Retzlaff's methods. The ml/kg RBW method disagreed with ICSH&Retzlaff's methods and ml/kg OBW in 25% and 19.2% of patients respectively. ICSH and Retzlaff's methods disagreed in 10/120 patients (8.3%). The ICSH method yielded significantly lower optimal volumes than Retzlaff's.
CONCLUSION: Three methods for optimal RCM&PV estimation lead to different interpretations of the same results of RCM&PV measurements with 51Cr-erythrocytes in 40% of patients. Two ml/kg body weight methods show greater disagreement in comparison with ICSH and Retzlaff's methods, which differ significantly. The ICSH method yields lower optimal values compared to Retzlaff's.
Keywords
labelled red blood cells; labelled erythrocytes; blood volume; 51Cr-sodium chromate; optimal plasma volume; optimal red blood cells mass; optimal erythrocytes volume
About this articleTitle
Clinical significance of optimal red cell mass and plasma volume estimation methods
Journal
Issue
Article type
Research paper
Pages
31-38
Published online
2004-01-22
Page views
575
Article views/downloads
1411
Bibliographic record
Nucl. Med. Rev 2004;7(1):31-38.
Keywords
labelled red blood cells
labelled erythrocytes
blood volume
51Cr-sodium chromate
optimal plasma volume
optimal red blood cells mass
optimal erythrocytes volume
Authors
Mila V. Todorović-Tirnanić
Smiljana V. Pavlović
Vladimir B. Obradović
Ivo V. Elezović
Dragomir Ž. Marisavljević
Peda S. Miljić
Rajko A. Milošević
Andrija D. Bogdanović
Vladimir B. Bošnjaković
