open access

Vol 7, No 1 (2004)
Original articles
Published online: 2004-01-22
Submitted: 2012-01-23
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Clinical significance of optimal red cell mass and plasma volume estimation methods

Mila V. Todorović-Tirnanić, Smiljana V. Pavlović, Vladimir B. Obradović, Ivo V. Elezović, Dragomir Ž. Marisavljević, Peda S. Miljić, Rajko A. Milošević, Andrija D. Bogdanović, Vladimir B. Bošnjaković
Nucl. Med. Rev 2004;7(1):31-38.

open access

Vol 7, No 1 (2004)
Original articles
Published online: 2004-01-22
Submitted: 2012-01-23

Abstract

BACKGROUND: The aim of this study was to present and compare the results of proposed methods for optimal red cell mass and plasma volume (RCM&PV) estimation, and their influence on the interpretation of obtained results.
MATERIAL AND METHODS: In 120/280 patients with polycythaemia rubra vera, subjected to RCM&PV determination with autologous erythrocytes in vitro labelled with 51Cr-sodium chromate, optimal volumes were determined using:
1. traditional ml/kg of:
- the real body weight method (ml/kg RBW);
- the optimal body weight method (ml/kg OBW).
2. the body weight, height, and sex based method (Retzlaff's tables),
3. the method recommended by the International Council for Standardization in Haematology (ICSH), based on body surface area.
RESULTS: Different interpretation of the same results of 120 RCM&PV measurements was registered in 48/120 patients (40%). The greatest disagreement existed between ml/kg RBW and ml/kg OBW methods (in 39/120 subjects, 32.5%). In underweight patients the ml/kg RBW method, and in overweight patients the ml/kg OBW method, offered better agreement with ICSH&Retzlaff's methods. The ml/kg RBW method disagreed with ICSH&Retzlaff's methods and ml/kg OBW in 25% and 19.2% of patients respectively. ICSH and Retzlaff's methods disagreed in 10/120 patients (8.3%). The ICSH method yielded significantly lower optimal volumes than Retzlaff's.
CONCLUSION: Three methods for optimal RCM&PV estimation lead to different interpretations of the same results of RCM&PV measurements with 51Cr-erythrocytes in 40% of patients. Two ml/kg body weight methods show greater disagreement in comparison with ICSH and Retzlaff's methods, which differ significantly. The ICSH method yields lower optimal values compared to Retzlaff's.

Abstract

BACKGROUND: The aim of this study was to present and compare the results of proposed methods for optimal red cell mass and plasma volume (RCM&PV) estimation, and their influence on the interpretation of obtained results.
MATERIAL AND METHODS: In 120/280 patients with polycythaemia rubra vera, subjected to RCM&PV determination with autologous erythrocytes in vitro labelled with 51Cr-sodium chromate, optimal volumes were determined using:
1. traditional ml/kg of:
- the real body weight method (ml/kg RBW);
- the optimal body weight method (ml/kg OBW).
2. the body weight, height, and sex based method (Retzlaff's tables),
3. the method recommended by the International Council for Standardization in Haematology (ICSH), based on body surface area.
RESULTS: Different interpretation of the same results of 120 RCM&PV measurements was registered in 48/120 patients (40%). The greatest disagreement existed between ml/kg RBW and ml/kg OBW methods (in 39/120 subjects, 32.5%). In underweight patients the ml/kg RBW method, and in overweight patients the ml/kg OBW method, offered better agreement with ICSH&Retzlaff's methods. The ml/kg RBW method disagreed with ICSH&Retzlaff's methods and ml/kg OBW in 25% and 19.2% of patients respectively. ICSH and Retzlaff's methods disagreed in 10/120 patients (8.3%). The ICSH method yielded significantly lower optimal volumes than Retzlaff's.
CONCLUSION: Three methods for optimal RCM&PV estimation lead to different interpretations of the same results of RCM&PV measurements with 51Cr-erythrocytes in 40% of patients. Two ml/kg body weight methods show greater disagreement in comparison with ICSH and Retzlaff's methods, which differ significantly. The ICSH method yields lower optimal values compared to Retzlaff's.
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Keywords

labelled red blood cells; labelled erythrocytes; blood volume; 51Cr-sodium chromate; optimal plasma volume; optimal red blood cells mass; optimal erythrocytes volume

About this article
Title

Clinical significance of optimal red cell mass and plasma volume estimation methods

Journal

Nuclear Medicine Review

Issue

Vol 7, No 1 (2004)

Pages

31-38

Published online

2004-01-22

Bibliographic record

Nucl. Med. Rev 2004;7(1):31-38.

Keywords

labelled red blood cells
labelled erythrocytes
blood volume
51Cr-sodium chromate
optimal plasma volume
optimal red blood cells mass
optimal erythrocytes volume

Authors

Mila V. Todorović-Tirnanić
Smiljana V. Pavlović
Vladimir B. Obradović
Ivo V. Elezović
Dragomir Ž. Marisavljević
Peda S. Miljić
Rajko A. Milošević
Andrija D. Bogdanović
Vladimir B. Bošnjaković

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