open access

Vol 7, No 2 (2004)
Published online: 2004-06-02
Submitted: 2012-01-23
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The prognostic value of dopamine receptor occupancy by [123I]IBZM-SPECT in schizophrenic patients treated with quetiapine

Lászlo Pávics, Gyorgy Szekeres, Edit Ambrus, Szabolcs Keri, Zoltan Kovacs, Miklos Argyelan, Balazs Kanyo, Laszlo Csernay, Zoltan Janka
Nucl. Med. Rev 2004;7(2):129-133.

open access

Vol 7, No 2 (2004)
Published online: 2004-06-02
Submitted: 2012-01-23

Abstract

BACKGROUND: In the present study D2 receptor occupancy was investigated in quetiapine treated schizophrenic patients for the detection of a relationship between the scintigraphic pattern and clinical signs and symptoms.
MATERIAL AND METHODS: In 10 schizophrenic patients [123I]IBZM-SPECTs were performed during the introduction of quetiapine therapy (600–800 mg/day) and during a lower maintenance dose (200–400 mg/day). The patients’ clinical follow-up was continued for 1 year. For the evaluation of SPECT images, visual interpretation was performed and striatum/occipital lobe (S/O) activity ratio was calculated.
RESULTS: The initial striatum/occipital ratio was significantly higher in patients with relapse compared to the others (1.86 ± 0.17, 1.53 ± 0.15, p < 0.01). The decreasing striatum/occipital ratio (increasing D2 receptor occupancy) on the 2nd SPECT was a predictive factor for the relapse.
CONCLUSIONS: D2 receptor occupancy and its changes during quetiapine therapy were related to the prognosis of the treatment efficacy.

Abstract

BACKGROUND: In the present study D2 receptor occupancy was investigated in quetiapine treated schizophrenic patients for the detection of a relationship between the scintigraphic pattern and clinical signs and symptoms.
MATERIAL AND METHODS: In 10 schizophrenic patients [123I]IBZM-SPECTs were performed during the introduction of quetiapine therapy (600–800 mg/day) and during a lower maintenance dose (200–400 mg/day). The patients’ clinical follow-up was continued for 1 year. For the evaluation of SPECT images, visual interpretation was performed and striatum/occipital lobe (S/O) activity ratio was calculated.
RESULTS: The initial striatum/occipital ratio was significantly higher in patients with relapse compared to the others (1.86 ± 0.17, 1.53 ± 0.15, p < 0.01). The decreasing striatum/occipital ratio (increasing D2 receptor occupancy) on the 2nd SPECT was a predictive factor for the relapse.
CONCLUSIONS: D2 receptor occupancy and its changes during quetiapine therapy were related to the prognosis of the treatment efficacy.
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Keywords

schizophrenia; quetiapine; IBZM-SPECT; clinical follow-up

About this article
Title

The prognostic value of dopamine receptor occupancy by [123I]IBZM-SPECT in schizophrenic patients treated with quetiapine

Journal

Nuclear Medicine Review

Issue

Vol 7, No 2 (2004)

Pages

129-133

Published online

2004-06-02

Bibliographic record

Nucl. Med. Rev 2004;7(2):129-133.

Keywords

schizophrenia
quetiapine
IBZM-SPECT
clinical follow-up

Authors

Lászlo Pávics
Gyorgy Szekeres
Edit Ambrus
Szabolcs Keri
Zoltan Kovacs
Miklos Argyelan
Balazs Kanyo
Laszlo Csernay
Zoltan Janka

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