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The prognostic value of dopamine receptor occupancy by [123I]IBZM-SPECT in schizophrenic patients treated with quetiapine
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Abstract
MATERIAL AND METHODS: In 10 schizophrenic patients [123I]IBZM-SPECTs were performed during the introduction of quetiapine therapy (600–800 mg/day) and during a lower maintenance dose (200–400 mg/day). The patients’ clinical follow-up was continued for 1 year. For the evaluation of SPECT images, visual interpretation was performed and striatum/occipital lobe (S/O) activity ratio was calculated.
RESULTS: The initial striatum/occipital ratio was significantly higher in patients with relapse compared to the others (1.86 ± 0.17, 1.53 ± 0.15, p < 0.01). The decreasing striatum/occipital ratio (increasing D2 receptor occupancy) on the 2nd SPECT was a predictive factor for the relapse.
CONCLUSIONS: D2 receptor occupancy and its changes during quetiapine therapy were related to the prognosis of the treatment efficacy.
Abstract
MATERIAL AND METHODS: In 10 schizophrenic patients [123I]IBZM-SPECTs were performed during the introduction of quetiapine therapy (600–800 mg/day) and during a lower maintenance dose (200–400 mg/day). The patients’ clinical follow-up was continued for 1 year. For the evaluation of SPECT images, visual interpretation was performed and striatum/occipital lobe (S/O) activity ratio was calculated.
RESULTS: The initial striatum/occipital ratio was significantly higher in patients with relapse compared to the others (1.86 ± 0.17, 1.53 ± 0.15, p < 0.01). The decreasing striatum/occipital ratio (increasing D2 receptor occupancy) on the 2nd SPECT was a predictive factor for the relapse.
CONCLUSIONS: D2 receptor occupancy and its changes during quetiapine therapy were related to the prognosis of the treatment efficacy.
Keywords
schizophrenia; quetiapine; IBZM-SPECT; clinical follow-up
About this articleTitle
The prognostic value of dopamine receptor occupancy by [123I]IBZM-SPECT in schizophrenic patients treated with quetiapine
Journal
Issue
Pages
129-133
Published online
2004-06-02
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601
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1464
Bibliographic record
Nucl. Med. Rev 2004;7(2):129-133.
Keywords
schizophrenia
quetiapine
IBZM-SPECT
clinical follow-up
Authors
Lászlo Pávics
Gyorgy Szekeres
Edit Ambrus
Szabolcs Keri
Zoltan Kovacs
Miklos Argyelan
Balazs Kanyo
Laszlo Csernay
Zoltan Janka
