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Relationship between plasma BNP levels and left ventricular diastolic function as measured by radionuclide ventriculography in patients with coronary artery disease
open access
Abstract
MATERIAL AND METHODS: The study population comprised 69 patients with CAD and 18 healthy subjects - a control group (CG). In all cases radionuclide ventriculography was performed at rest and the plasma BNP level was estimated.
RESULTS: The plasma BNP concentration was significantly higher in the group with CAD than in those with CG . In patients with CAD and a decreased LVEF (dEF), the BNP level was significantly higher than in those with normal LVEF (nEF). In the subgroup with nEF and an AFR ≤ 1.04 EDV/s, the level of plasma BNP was significantly higher than in that with an AFR >1.04. In the total CAD group, a significant correlation was found between plasma BNP concentrations and the LVEF, PER and AFR. In patients with nEF, the level of plasma BNP correlated only with the AFR.
CONCLUSIONS: It is concluded that the diastolic dysfunction of the left ventricle in patients with CAD leads to an elevation of plasma BNP concentrations despite the normal ejection fraction. A diastolic dysfunction of the left ventricle affects the BNP plasma concentration to a greater degree than a systolic dysfunction.
Abstract
MATERIAL AND METHODS: The study population comprised 69 patients with CAD and 18 healthy subjects - a control group (CG). In all cases radionuclide ventriculography was performed at rest and the plasma BNP level was estimated.
RESULTS: The plasma BNP concentration was significantly higher in the group with CAD than in those with CG . In patients with CAD and a decreased LVEF (dEF), the BNP level was significantly higher than in those with normal LVEF (nEF). In the subgroup with nEF and an AFR ≤ 1.04 EDV/s, the level of plasma BNP was significantly higher than in that with an AFR >1.04. In the total CAD group, a significant correlation was found between plasma BNP concentrations and the LVEF, PER and AFR. In patients with nEF, the level of plasma BNP correlated only with the AFR.
CONCLUSIONS: It is concluded that the diastolic dysfunction of the left ventricle in patients with CAD leads to an elevation of plasma BNP concentrations despite the normal ejection fraction. A diastolic dysfunction of the left ventricle affects the BNP plasma concentration to a greater degree than a systolic dysfunction.
Keywords
radionuclide ventriculography; BNP; LV diastolic function; CAD
Title
Relationship between plasma BNP levels and left ventricular diastolic function as measured by radionuclide ventriculography in patients with coronary artery disease
Journal
Issue
Pages
123-128
Published online
2004-06-02
Page views
585
Article views/downloads
1284
Bibliographic record
Nucl. Med. Rev 2004;7(2):123-128.
Keywords
radionuclide ventriculography
BNP
LV diastolic function
CAD
Authors
Rafał Celiński
Witold Cholewiński
Bogusław Stefaniak
Anna Tarkowska