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The case of Cushing's disease imaging by SPECT examination without manifestation of pituitary adenoma in MRI examination
open access
Abstract
MATERIAL AND METHODS: Cushing's disease was diagnosed in a 27 year old male on the basis of clinical and biochemical findings. The blood cortisol level of the patient was elevated (the average level was 47 ug/dl) and it showed no changeability of day and night rhythm.
RESULTS: In the patient with Cushing's disease, during the SPECT examination, an increased accumulation of 99mTc-MIBI in the pituitary gland was noticed. MRI scanning was negative.
CONCLUSION: Single photon emission computed tomography using 99mTc-MIBI is a useful and sensitive means of pituitary gland microadenoma detection in patients with Cushing's disease when microadenoma is not detected during MRI scanning and when the results of dexamethasone suppression test is positive.
Abstract
MATERIAL AND METHODS: Cushing's disease was diagnosed in a 27 year old male on the basis of clinical and biochemical findings. The blood cortisol level of the patient was elevated (the average level was 47 ug/dl) and it showed no changeability of day and night rhythm.
RESULTS: In the patient with Cushing's disease, during the SPECT examination, an increased accumulation of 99mTc-MIBI in the pituitary gland was noticed. MRI scanning was negative.
CONCLUSION: Single photon emission computed tomography using 99mTc-MIBI is a useful and sensitive means of pituitary gland microadenoma detection in patients with Cushing's disease when microadenoma is not detected during MRI scanning and when the results of dexamethasone suppression test is positive.
Keywords
Cushing disease; SPECT; MRI
Title
The case of Cushing's disease imaging by SPECT examination without manifestation of pituitary adenoma in MRI examination
Journal
Issue
Pages
137-139
Published online
2005-06-23
Page views
559
Article views/downloads
1272
Bibliographic record
Nucl. Med. Rev 2005;8(2):137-139.
Keywords
Cushing disease
SPECT
MRI
Authors
Marcin Gierach
Joanna Pufal
Stanisław Pilecki
Roman Junik