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Vol 11, No 1 (2008)
Submitted: 2012-01-23
Published online: 2008-01-15
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Evaluation of [201Tl](III) Vancomycin in normal rats

Amir Reza Jalilian, Mohammad Amin Hosseini, Abbas Majdabadi, Fariba Saddadi
Nucl. Med. Rev 2008;11(1):1-4.

open access

Vol 11, No 1 (2008)
Submitted: 2012-01-23
Published online: 2008-01-15

Abstract

BACKGROUND: Tl-201 has potential in the preparation of radiolabelled compounds similar to its homologues, like In-111 and radiogallium. In this paper, recently prepared [201Tl](III) vancomycin complex ([201Tl](III)VAN) has been evaluated for its biological properties.
MATERIAL AND METHODS: [201Tl](III)VAN was prepared according to the optimized conditions followed by biodistribution studies in normal rats for up to 52 h. The Staphylococcus aurous specific binding was checked in vitro. The complex was finally injected to normal rats. Tracer SPECT images were obtained in normal animals and compared to those of 67Ga-citrate.
RESULTS: Freshly-prepared [201Tl](III)VAN batches (radiochemical yield > 99%, radiochemical purity > 98%, specific activity ≈ 1.2 Ci/mmol) showed a similar biodistribution to that of unlabeled vancomycin. The microorganism binding ratios were 3 and 9 for tracer 201Tl3+ and tracer 201Tl(III)DTPA, respectively, suggesting the preservation of the tracer bioactivity. As a nonspecific cell penetrating tracer, [201Tl](III)DTPA was used.

Abstract

BACKGROUND: Tl-201 has potential in the preparation of radiolabelled compounds similar to its homologues, like In-111 and radiogallium. In this paper, recently prepared [201Tl](III) vancomycin complex ([201Tl](III)VAN) has been evaluated for its biological properties.
MATERIAL AND METHODS: [201Tl](III)VAN was prepared according to the optimized conditions followed by biodistribution studies in normal rats for up to 52 h. The Staphylococcus aurous specific binding was checked in vitro. The complex was finally injected to normal rats. Tracer SPECT images were obtained in normal animals and compared to those of 67Ga-citrate.
RESULTS: Freshly-prepared [201Tl](III)VAN batches (radiochemical yield > 99%, radiochemical purity > 98%, specific activity ≈ 1.2 Ci/mmol) showed a similar biodistribution to that of unlabeled vancomycin. The microorganism binding ratios were 3 and 9 for tracer 201Tl3+ and tracer 201Tl(III)DTPA, respectively, suggesting the preservation of the tracer bioactivity. As a nonspecific cell penetrating tracer, [201Tl](III)DTPA was used.

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Keywords

Tl-201; vancomycin; SPECT; biodistribution; Staphylococcus aureus; binding study

About this article
Title

Evaluation of [201Tl](III) Vancomycin in normal rats

Journal

Nuclear Medicine Review

Issue

Vol 11, No 1 (2008)

Pages

1-4

Published online

2008-01-15

Page views

703

Article views/downloads

1239

Bibliographic record

Nucl. Med. Rev 2008;11(1):1-4.

Keywords

Tl-201
vancomycin
SPECT
biodistribution
Staphylococcus aureus
binding study

Authors

Amir Reza Jalilian
Mohammad Amin Hosseini
Abbas Majdabadi
Fariba Saddadi

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