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Age-related changes in skull uptake on bone scintigraphy: a quantitative study
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Abstract
MATERIAL AND METHODS: We semi-quantitatively studied 342 normal bone scans (161 male and 181 female within the age range 12 to 82 years). We divided the patients into 7 age groups: 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, and 70 and above. The geometric means of the anterior and posterior background corrected skull and mid-femoral ROI values were used for calculation of the skull to femoral ratio (SFR).
RESULTS: The skull to femoral ratio was significantly higher in female patients in the age groups 30-39 and above. In females, the five upper age groups (30-39, 40-49, 50-59, 60-69, and 70 and above) had significantly higher SFR than the lower age groups. In males, the two upper age groups (60-69, 70 and above) had significantly higher SFR than the lower age groups. The findings in males were not concordant with the previous studies addressing this issue, which could be explained by different bone mineral density in the Iranian population.
CONCLUSION: Our data showed that “hot skull” is not necessarily an abnormal finding, especially in elderly women. We suggest that every nuclear medicine department uses its own normal values and reference samples for quantitative evaluation, due to ethnic or socio-economical variations.
Abstract
MATERIAL AND METHODS: We semi-quantitatively studied 342 normal bone scans (161 male and 181 female within the age range 12 to 82 years). We divided the patients into 7 age groups: 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, and 70 and above. The geometric means of the anterior and posterior background corrected skull and mid-femoral ROI values were used for calculation of the skull to femoral ratio (SFR).
RESULTS: The skull to femoral ratio was significantly higher in female patients in the age groups 30-39 and above. In females, the five upper age groups (30-39, 40-49, 50-59, 60-69, and 70 and above) had significantly higher SFR than the lower age groups. In males, the two upper age groups (60-69, 70 and above) had significantly higher SFR than the lower age groups. The findings in males were not concordant with the previous studies addressing this issue, which could be explained by different bone mineral density in the Iranian population.
CONCLUSION: Our data showed that “hot skull” is not necessarily an abnormal finding, especially in elderly women. We suggest that every nuclear medicine department uses its own normal values and reference samples for quantitative evaluation, due to ethnic or socio-economical variations.
Keywords
bone scan; skull; osteoporosis; methylen diphosphonate; age
Title
Age-related changes in skull uptake on bone scintigraphy: a quantitative study
Journal
Issue
Pages
67-69
Published online
2008-11-05
Page views
616
Article views/downloads
3034
Bibliographic record
Nucl. Med. Rev 2008;11(2):67-69.
Keywords
bone scan
skull
osteoporosis
methylen diphosphonate
age
Authors
Ramin Sadeghi
Seyed Rasoul Zakavi
Masrour Ghasemov
Vahid Reza Dabbagh Kakhki