open access

Vol 11, No 2 (2008)
Published online: 2008-11-05
Submitted: 2012-01-23
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Impact of CT based attenuation correction on quantitative assessment of DaTSCAN (123I-Ioflupane) imaging in diagnosis of extrapyramidal diseases

Małgorzata Bieńkiewicz, Magdalena Górska-Chrząstek, Jakub Siennicki, Agata Gajos, Andrzej Bogucki, Alina Mochecka-Thoelke, Anna Płachcińska, Jacek Kuśmierek
Nucl. Med. Rev 2008;11(2):53-58.

open access

Vol 11, No 2 (2008)
Published online: 2008-11-05
Submitted: 2012-01-23

Abstract

The quality of visually and semi-quantitatively assessed DaTSCAN images is crucial for differential diagnostics of extrapyramidal diseases. Neuroimaging with the use of presynaptic tracers of the dopaminergic system provides evidence of nigrostriatal degeneration and may support the clinical diagnosis of Parkinsonism. During the last two years (2007–2008) we tried to elaborate the optimal methodology of SPECT/CT examination with the use of DaTSCAN (123I-Ioflupane), and we sought to evaluate the effect of the reconstruction and attenuation correction method on semi-quantitative measures of relative uptake in the striatum.
In a present study, we retrospectively studied DaTSCAN scans of 44 consecutive patients with clinical indications of Parkinson’s disease or uncertain Parkinsonian syndromes. The quality of DaTSCAN images reconstructed with the use of ordered-subset expectation maximization reconstruction technique (OSEM) with attenuation correction based on CT maps was found to be superior to that provided by the commonly applied filtered backprojection method (FBP) with Chang attenuation correction. OSEM reconstructed transverse slices were more legible for clinical interpretation because of increased contrast and improved delineation between striatum structures. Semi-quantitative assessments of relative striatum uptake for OSEM reconstructed slices secured better intra-operator reproducibility than that obtained by FBP method.

Abstract

The quality of visually and semi-quantitatively assessed DaTSCAN images is crucial for differential diagnostics of extrapyramidal diseases. Neuroimaging with the use of presynaptic tracers of the dopaminergic system provides evidence of nigrostriatal degeneration and may support the clinical diagnosis of Parkinsonism. During the last two years (2007–2008) we tried to elaborate the optimal methodology of SPECT/CT examination with the use of DaTSCAN (123I-Ioflupane), and we sought to evaluate the effect of the reconstruction and attenuation correction method on semi-quantitative measures of relative uptake in the striatum.
In a present study, we retrospectively studied DaTSCAN scans of 44 consecutive patients with clinical indications of Parkinson’s disease or uncertain Parkinsonian syndromes. The quality of DaTSCAN images reconstructed with the use of ordered-subset expectation maximization reconstruction technique (OSEM) with attenuation correction based on CT maps was found to be superior to that provided by the commonly applied filtered backprojection method (FBP) with Chang attenuation correction. OSEM reconstructed transverse slices were more legible for clinical interpretation because of increased contrast and improved delineation between striatum structures. Semi-quantitative assessments of relative striatum uptake for OSEM reconstructed slices secured better intra-operator reproducibility than that obtained by FBP method.
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Keywords

SPECT/CT DaTSCAN imaging; Parkinson disease; striatal dopamine transporter activity; iterative reconstruction technique

About this article
Title

Impact of CT based attenuation correction on quantitative assessment of DaTSCAN (123I-Ioflupane) imaging in diagnosis of extrapyramidal diseases

Journal

Nuclear Medicine Review

Issue

Vol 11, No 2 (2008)

Pages

53-58

Published online

2008-11-05

Bibliographic record

Nucl. Med. Rev 2008;11(2):53-58.

Keywords

SPECT/CT DaTSCAN imaging
Parkinson disease
striatal dopamine transporter activity
iterative reconstruction technique

Authors

Małgorzata Bieńkiewicz
Magdalena Górska-Chrząstek
Jakub Siennicki
Agata Gajos
Andrzej Bogucki
Alina Mochecka-Thoelke
Anna Płachcińska
Jacek Kuśmierek

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