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Impact of CT based attenuation correction on quantitative assessment of DaTSCAN (123I-Ioflupane) imaging in diagnosis of extrapyramidal diseases
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Abstract
In a present study, we retrospectively studied DaTSCAN scans of 44 consecutive patients with clinical indications of Parkinson’s disease or uncertain Parkinsonian syndromes. The quality of DaTSCAN images reconstructed with the use of ordered-subset expectation maximization reconstruction technique (OSEM) with attenuation correction based on CT maps was found to be superior to that provided by the commonly applied filtered backprojection method (FBP) with Chang attenuation correction. OSEM reconstructed transverse slices were more legible for clinical interpretation because of increased contrast and improved delineation between striatum structures. Semi-quantitative assessments of relative striatum uptake for OSEM reconstructed slices secured better intra-operator reproducibility than that obtained by FBP method.
Abstract
In a present study, we retrospectively studied DaTSCAN scans of 44 consecutive patients with clinical indications of Parkinson’s disease or uncertain Parkinsonian syndromes. The quality of DaTSCAN images reconstructed with the use of ordered-subset expectation maximization reconstruction technique (OSEM) with attenuation correction based on CT maps was found to be superior to that provided by the commonly applied filtered backprojection method (FBP) with Chang attenuation correction. OSEM reconstructed transverse slices were more legible for clinical interpretation because of increased contrast and improved delineation between striatum structures. Semi-quantitative assessments of relative striatum uptake for OSEM reconstructed slices secured better intra-operator reproducibility than that obtained by FBP method.
Keywords
SPECT/CT DaTSCAN imaging; Parkinson disease; striatal dopamine transporter activity; iterative reconstruction technique
Title
Impact of CT based attenuation correction on quantitative assessment of DaTSCAN (123I-Ioflupane) imaging in diagnosis of extrapyramidal diseases
Journal
Issue
Pages
53-58
Published online
2008-11-05
Page views
730
Article views/downloads
1769
Bibliographic record
Nucl. Med. Rev 2008;11(2):53-58.
Keywords
SPECT/CT DaTSCAN imaging
Parkinson disease
striatal dopamine transporter activity
iterative reconstruction technique
Authors
Małgorzata Bieńkiewicz
Magdalena Górska-Chrząstek
Jakub Siennicki
Agata Gajos
Andrzej Bogucki
Alina Mochecka-Thoelke
Anna Płachcińska
Jacek Kuśmierek