open access

Vol 69, No 3-4 (2019)
Review articles
Published online: 2019-10-31
Get Citation

HE4 – not only an ovarian cancer biomarker – a brief review

Marta Maksimiuk, Michał P. Budzik, Andrzej Deptała, Anna M. Badowska-Kozakiewicz
DOI: 10.5603/NJO.2019.0026
·
Nowotwory. Journal of Oncology 2019;69(3-4):142-145.

open access

Vol 69, No 3-4 (2019)
Review articles
Published online: 2019-10-31

Abstract

Human epididymis protein 4 (HE4) was firstly identified in epididymal epithelial cells and described as a protease inhibitor playing a role in spermatogenesis. Regarding numerous studies proving its diverse potential as a prognostic and predictive factor in ovarian cancer, it was incorporated into ROMA algorithm. Nevertheless, recent studies have shown that serum level of HE4 is not exclusive to ovarian cancer. As a result, doctors using ROMA algorithm for stratifying patients with ovarian cancer must be aware of other conditions that may affect serum level of HE4. This review comprises different conditions connected with high level of HE4 that might impact ovarian cancer diagnosing process. Moreover, discovering increased HE4 level in various conditions should open discussion about its applicability in diseases other than ovarian cancer.

Abstract

Human epididymis protein 4 (HE4) was firstly identified in epididymal epithelial cells and described as a protease inhibitor playing a role in spermatogenesis. Regarding numerous studies proving its diverse potential as a prognostic and predictive factor in ovarian cancer, it was incorporated into ROMA algorithm. Nevertheless, recent studies have shown that serum level of HE4 is not exclusive to ovarian cancer. As a result, doctors using ROMA algorithm for stratifying patients with ovarian cancer must be aware of other conditions that may affect serum level of HE4. This review comprises different conditions connected with high level of HE4 that might impact ovarian cancer diagnosing process. Moreover, discovering increased HE4 level in various conditions should open discussion about its applicability in diseases other than ovarian cancer.

Get Citation

Keywords

human epididymis protein 4; ovarian cancer; ROMA algorithm; biomarkers

About this article
Title

HE4 – not only an ovarian cancer biomarker – a brief review

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 3-4 (2019)

Pages

142-145

Published online

2019-10-31

DOI

10.5603/NJO.2019.0026

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(3-4):142-145.

Keywords

human epididymis protein 4
ovarian cancer
ROMA algorithm
biomarkers

Authors

Marta Maksimiuk
Michał P. Budzik
Andrzej Deptała
Anna M. Badowska-Kozakiewicz

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