Vol 73, No 2 (2023)
Review paper
Published online: 2023-03-15

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Non-smoking lung cancer and environmental exposure

Mark Parascandola1
Nowotwory. Journal of Oncology 2023;73(2):103-108.

Abstract

While lung cancer mortality has been decreasing in many countries due to tobacco control efforts, at least one quarter of global lung cancer cases occur among non-smokers. There is growing attention being paid to the role of environmental exposures, such as radon and air pollution, in lung cancer. Additionally, recent research efforts have sought to elucidate the distinct characteristics of and mechanisms involved in lung cancer among never smokers. Continued research on non-smoking lung cancer is critical to identifying new opportunities for intervention and addressing the global burden of lung cancer.

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References

  1. Thun M, Peto R, Boreham J, et al. Stages of the cigarette epidemic on entering its second century. Tob Control. 2012; 21(2): 96–101.
  2. Zatonski WA, Zatonski M. Poland’s rapid lung cancer decline in the years 1990¬2016: The first steps towards the eradication of lung cancer in Poland. Health Prob Civil. 2017; 11: 211–225.
  3. Zatoński WA, Sulkowska U, Didkowska J. Cancer epidemiology in Poland. NOWOTWORY Journal of Oncology. 2015; 65(3): 179–196.
  4. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209–249.
  5. National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Centers for Disease Control and Prevention (US), Atlanta (GA) 2014.
  6. Zheng W, McLerran DF, Rolland BA, et al. Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts. PLoS Med. 2014; 11(4): e1001631.
  7. Begley S. ‘But I never smoked’: A growing share of lung cancer cases is turning up in an unexpected population. Stat. Jan. 26, 2021. https://www.statnews.com/2021/01/26/growing-share-of-lung-cancer-turning-up-in-never-smokers/.
  8. https://triblive.com/news/pennsylvania/radon-effecting-change-women-spurred-revised-laws-pennsylvania/.
  9. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209–249.
  10. Liu X, Yu Y, Wang M, et al. The mortality of lung cancer attributable to smoking among adults in China and the United States during 1990-2017. Cancer Commun (Lond). 2020; 40(11): 611–619.
  11. Greenberg M, Selikoff IJ. Lung cancer in the Schneeberg mines: a reappraisal of the data reported by Harting and Hesse in 1879. Ann Occup Hyg. 1993; 37(1): 5–14.
  12. DOLL R, HILL AB. Smoking and carcinoma of the lung; preliminary report. Br Med J. 1950; 2(4682): 739–748.
  13. Motor Vehicles, Air Pollution and Health. A Report of the Surgeon General to the U.S. Congress. Volume 1: Summary – A Review of the Problem. U.S. Department of Health, Education and Welfare, Public Health Service, Division of Air Pollution, Washington DC 1962.
  14. Motor Vehicles, Air Pollution and HU.S. Department of Health, Education, and Welfare. Smoking and Health: Report of the Advisory Committee to the Surgeon General of the Public Health Service. PHS Publication No. 1103. U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, Washington DC 1964.
  15. American Cancer Society. Known and Probably Carcinogens. https://www.cancer.org/healthy/cancer-causes/general-info/known-and-probable-human-carcinogens.html (08.07.2022).
  16. Outdoor Air Pollution. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 109. IARC 2015.
  17. Turner MC, Andersen ZJ, Baccarelli A, et al. Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations. CA Cancer J Clin. 2020 [Epub ahead of print].
  18. Hamra GB, Laden F, Cohen AJ, et al. Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ Health Perspect. 2014; 122(9): 906–911.
  19. Huang F, Pan B, Wu J, et al. Relationship between exposure to PM2.5 and lung cancer incidence and mortality: A meta-analysis. Oncotarget. 2017; 8(26): 43322–43331.
  20. Darby S, Hill D, Auvinen A, et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. 2005; 330(7485): 223.
  21. Selikoff IJ, Hammond EC, Churg J. Asbestos Exposure, Smoking, and Neoplasia. JAMA. 1968; 204(2): 106–112.
  22. Hiatt RA, Beyeler N, Hiatt RA, et al. Cancer and climate change. Lancet Oncol. 2020; 21(11): e519–e527.
  23. Thun MJ, Hannan LM, Adams-Campbell LL, et al. Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med. 2008; 5(9): e185.
  24. Couraud S, Souquet PJ, Paris C, et al. French Cooperative Intergroup IFCT. BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers. Eur Respir J. 2015; 45(5): 1403–1414.
  25. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016; 66(2): 115–132.
  26. Xue Y, Jiang Y, Jin S, et al. Association between cooking oil fume exposure and lung cancer among Chinese nonsmoking women: a meta-analysis. Onco Targets Ther. 2016; 9: 2987–2992.
  27. Zhao Yu, Wang S, Aunan K, et al. Air pollution and lung cancer risks in China--a meta-analysis. Sci Total Environ. 2006; 366(2-3): 500–513.
  28. Xu ZY, Blot WJ, Fraumeni JF. Geographic variation of female lung cancer in China. Am J Public Health. 1986; 76(10): 1249–1250.
  29. Cao Q, Rui G, Liang Y. Study on PM2.5 pollution and the mortality due to lung cancer in China based on geographic weighted regression model. BMC Public Health. 2018; 18(1): 925.
  30. Guo Y, Zeng H, Zheng R, et al. The burden of lung cancer mortality attributable to fine particles in China. Sci Total Environ. 2017; 579: 1460–1466.
  31. Surge in 'non-smoking' lung cancer in China. The Straits Times. August 12, 2017. https://www. straitstimes.com/asia/east-asia/surge-in-non-smoking- lung-cancer-in-china.
  32. Thun MJ, Lally CA, Flannery JT, et al. Cigarette smoking and changes in the histopathology of lung cancer. J Natl Cancer Inst. 1997; 89(21): 1580–1586.
  33. Parascandola M, Xiao L. Tobacco and the lung cancer epidemic in China. Transl Lung Cancer Res. 2019; 8(Suppl 1): S21–S30.
  34. Singh N, Agrawal S, Jiwnani S, et al. Lung Cancer in India. J Thorac Oncol. 2021; 16(8): 1250–1266.
  35. Tseng CH, Tsuang BJ, Chiang CJ, et al. The Relationship Between Air Pollution and Lung Cancer in Nonsmokers in Taiwan. J Thorac Oncol. 2019; 14(5): 784–792.
  36. Planchard D, Besse B. Lung cancer in never-smokers. Eur Respir J. 2015; 45(5): 1214–1217.
  37. Zhang T, Joubert P, Ansari-Pour N, et al. Genomic and evolutionary classification of lung cancer in never smokers. Nat Genet. 2021; 53(9): 1348–1359.
  38. Chevallier M, Borgeaud M, Addeo A, et al. Oncogenic driver mutations in non-small cell lung cancer: Past, present and future. World J Clin Oncol. 2021; 12(4): 217–237.
  39. Researchers Examine How Air Pollution May Drive Lung Cancer in Never-Smokers. The ASCO Post. September 10, 2022. https://ascopost.com/news/september-2022/researchers-examine-how-air-pollution-may-drive-lung-cancer-in-neversmokers/.
  40. Quinn AK, Williams KN, Thompson LM, et al. Fidelity and Adherence to a Liquefied Petroleum Gas Stove and Fuel Intervention during Gestation: The Multi-Country Household Air Pollution Intervention Network (HAPIN) Randomized Controlled Trial. Int J Environ Res Public Health. 2021; 18(23).
  41. PDQ® Screening and Prevention Editorial Board. PDQ Lung Cancer Screening. Bethesda, MD: National Cancer Institute. https://www.cancer.gov/types/lung/patient/lung-screening-pdq (31.10.2022).
  42. Williamson TJ, Kwon DM, Riley KE, et al. Lung Cancer Stigma: Does Smoking History Matter? Ann Behav Med. 2020; 54(7): 535–540.



Nowotwory. Journal of Oncology