Vol 73, No 2 (2023)
Review paper
Published online: 2022-12-16

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Cancerogenic food contaminants in European countries

Elwira Gliwska12, Paweł Koczkodaj1, Marta Mańczuk1
Nowotwory. Journal of Oncology 2023;73(2):95-102.

Abstract

Contamination of food is inevitable in the production process from manufacturing to preparation for consumption. Some of the contaminants in food are serious health hazards and may increase the risk of cancer. Carcinogenic food contaminants include mycotoxins, dioxins, benzopyrene, acrylamide, cadmium and arsenic. European Union countries are required to meet standards for individual contaminants that may be present in food and to monitor these contami­nants in products on the market. However, based on the European warning system for carcinogenic contaminants, it can be seen that they are still present in various countries of the EU. In view of the increasing number of cancer cases and the overall burden of non-communicable diseases on society, it is recommended to consider not only the nutritional value of food, but also the contamination of food with carcinogenic substances.

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References

  1. Dyba T, Randi G, Bray F, et al. The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers. Eur J Cancer. 2021; 157: 308–347.
  2. Paleczna M. Cancer as a chronic disease — a psychological perspective. Nowotwory. Journal of Oncology. 2018; 68(1): 28–32.
  3. Cabasag CJ, Vignat J, Ferlay J, et al. The preventability of cancer in Europe: A quantitative assessment of avoidable cancer cases across 17 cancer sites and 38 countries in 2020. Eur J Cancer. 2022; 177: 15–24.
  4. Grasgruber P, Hrazdira E, Sebera M, et al. Cancer Incidence in Europe: An Ecological Analysis of Nutritional and Other Environmental Factors. Front Oncol. 2018; 8: 151.
  5. GBD 2019 Cancer Risk Factors Collaborators. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022; 400(10352): 563–591.
  6. Nerín C, Aznar M, Carrizo D. Food contamination during food process. Trends in Food Science & Technology. 2016; 48: 63–68.
  7. Thinking about the future of food safety. 2022.
  8. Cancer IA for R on. IARC monographs on the identification of carcinogenic hazards to humans. WHO 2019.
  9. Council Regulation (EEC) No 315/93 of 8 February 1993 laying down Community procedures for contaminants in food. Off J L. 1993; 37: 1–3.
  10. Commission E. Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union. 2006; 364: 5–24.
  11. EC. Regulation No 178/2002 of the European Parliament and of the Council. Off J Eur Union. 2022; 1.
  12. Claeys L, Romano C, De Ruyck K, et al. Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies. Compr Rev Food Sci Food Saf. 2020; 19(4): 1449–1464.
  13. IARC monographs on the evaluation of carcinogenic risks to humans. Some Ind Chem. Lyon, France. 1994; 60: 389–433.
  14. Chhonker S, Rawat D, Naik RA, et al. An overview of mycotoxins in human health with emphasis on development and progression of liver cancer. Clin Oncol. 2018; 3: 1408.
  15. Muñoz K, Wagner M, Pauli F, et al. Knowledge and Behavioral Habits to Reduce Mycotoxin Dietary Exposure at Household Level in a Cohort of German University Students. Toxins (Basel). 2021; 13(11).
  16. Strucinski P, Piskorska-Pliszczynska J, Góralczyk K, et al. Dioksyny a bezpieczeństwo żywności. Rocz Państwowego Zakładu Hig. 2011; 62(1).
  17. Hays SM, Aylward LL. Dioxin risks in perspective: past, present, and future. Regul Toxicol Pharmacol. 2003; 37(2): 202–217.
  18. Larsen JC. Risk assessments of polychlorinated dibenzo- p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in food. Mol Nutr Food Res. 2006; 50(10): 885–896.
  19. Parzefall W. Risk assessment of dioxin contamination in human food. Food Chem Toxicol. 2002; 40(8): 1185–1189.
  20. Brzeski Z. Dioksyny i furany w środowisku i ich wpływ na organizm. Med Ogólna i Nauk o Zdrowiu. 2011; 17(3).
  21. Całkosiński I, Rosińczuk-Tonderys J, Szopa M, et al. Zastosowanie wysokich dawek tokoferolu w prewencji i potencjalizacji działania dioksyn w doświadczalnym zapaleniu. Postepy Hig Med Dosw (Online). 2011; 65: 143–157.
  22. WHO Evaluation of certain food additives and contaminants. World Health Organization Tech Rep Ser. 2000; 896.
  23. Yaktine AL, Harrison GG, Lawrence RS. Reducing exposure to dioxins and related compounds through foods in the next generation. Nutr Rev. 2006; 64(9): 403–409.
  24. Butler JP, Post GB, Lioy PJ, et al. Assessment of carcinogenic risk from personal exposure to benzo(a)pyrene in the Total Human Environmental Exposure Study (THEES). Air Waste. 1993; 43(7): 970–977.
  25. Angerer J, Mannschreck C, Gündel J, et al. Occupational exposure to polycyclic aromatic hydrocarbons in a graphite-electrode producing plant: biological monitoring of 1-hydroxypyrene and monohydroxylated metabolites of phenanthrene. Int Arch Occup Environ Health. 1997; 69(5): 323–331.
  26. van Schooten FJ, Moonen EJ, van der Wal L, et al. Determination of polycyclic aromatic hydrocarbons (PAH) and their metabolites in blood, feces, and urine of rats orally exposed to PAH contaminated soils. Arch Environ Contam Toxicol. 1997; 33(3): 317–322.
  27. Zasadowski A, Wysocki A. [Some toxicological aspects of polycyclic aromatic hydrocarbons (PAHs) effects]. Rocz Panstw Zakl Hig. 2002; 1(53): 33–45.
  28. Tzeng HP, Lan KC, Yang TH, et al. Benzo[a]pyrene activates interleukin-6 induction and suppresses nitric oxide-induced apoptosis in rat vascular smooth muscle cells. PLoS One. 2017; 12(5): e0178063.
  29. Yuan Li, Liu J, Deng H, et al. Benzo[a]pyrene Induces Autophagic and Pyroptotic Death Simultaneously in HL-7702 Human Normal Liver Cells. J Agric Food Chem. 2017; 65(44): 9763–9773.
  30. IARC. A review of human carcinogens. Part F: Chemical agents and related occupations / IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC monographs. 2012; 100F: 134–137.
  31. Bukowska B, Mokra K, Michałowicz J. Benzo[]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity. Int J Mol Sci. 2022; 23(11).
  32. Scientific Opinion on acrylamide in food. EFSA Journal. 2015; 13(6).
  33. Kita A, Bråthen E, Knutsen SH, et al. Effective ways of decreasing acrylamide content in potato crisps during processing. J Agric Food Chem. 2004; 52(23): 7011–7016.
  34. Sarwar N, Malhi SS, Zia MH, et al. Saifullah. Role of mineral nutrition in minimizing cadmium accumulation by plants. J Sci Food Agric. 2010; 90(6): 925–937.
  35. Chunhabundit R. Cadmium Exposure and Potential Health Risk from Foods in Contaminated Area, Thailand. Toxicol Res. 2016; 32(1): 65–72.
  36. Sabath E, Robles-Osorio ML. Renal health and the environment: heavy metal nephrotoxicity. Nefrologia. 2012; 32(3): 279–286.
  37. Haswell-Elkins M, Imray P, Satarug S, et al. Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods. J Expo Sci Environ Epidemiol. 2007; 17(4): 372–377.
  38. Callan AC, Devine A, Qi L, et al. Investigation of the relationship between low environmental exposure to metals and bone mineral density, bone resorption and renal function. Int J Hyg Environ Health. 2015; 218(5): 444–451.
  39. Bishak YK, Payahoo L, Osatdrahimi A, et al. Mechanisms of cadmium carcinogenicity in the gastrointestinal tract. Asian Pac J Cancer Prev. 2015; 16(1): 9–21.
  40. IARC. Cadmium and cadmium compounds. In: Beryllium, Cadmium, Mercury, and Exposures in the Glass Manufacturing Industry. International Agency for Research on Cancer. 1993; 58.
  41. World Health Organization. Preventing Disease through Healthy Environments Exposure to Cadmium: A Major Public Health Concern; World Health Organization: Geneva, Switzerland, 2010. http://www.who.int/ipcs/features/cadmium.pdf (12.10.2022).
  42. Rudnai T, Sándor J, Kádár M, et al. Arsenic in drinking water and congenital heart anomalies in Hungary. Int J Hyg Environ Health. 2014; 217(8): 813–818.
  43. Khosravi-Darani K, Rehman Y, Katsoyiannis I, et al. Arsenic Exposure via Contaminated Water and Food Sources. Water. 2022; 14(12): 1884.
  44. Kulik-Kupka K, Koszowska A, Brończyk-Puzoń A, et al. Arsenic – Poison or medicine? Medycyna Pracy. 2016; 67(1): 89–96.
  45. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. "Arsenic and arsenic compounds." Arsenic, Metals, Fibres and Dusts. International Agency for Research on Cancer. 2012.
  46. Wierzbicka E. Occurrence of Arsenic in Food as a Current Health Concern. Postępy Tech Przetwórstwa Spożywczego. 2021; 2: 194–206.