open access

Vol 72, No 5 (2022)
Research paper (original)
Published online: 2022-08-26
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Cardiotoxicity in patients with early breast cancer treated with adjuvant trastuzumab

Joanna Kufel-Grabowska1, Sławomir Katarzyński2, Sebastian Szmit3, Mikołaj Bartoszkiewicz4, Maria Litwiniuk5
DOI: 10.5603/NJO.a2022.0047
·
Nowotwory. Journal of Oncology 2022;72(5):288-293.
Affiliations
  1. Department of Chemotherapy, Clinical Hospital Heliodor Swiecicki in Poznan, Poznan, Poland
  2. Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland
  3. Department and Clinic of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, CMKP, Institute of Hematology and Transfusion Medicine, Otwock, Poland
  4. Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland
  5. Department of Pathology and Cancer Prevention, Poznan University of Medical Sciences, Poznan, Poland, Greater Poland Cancer Center, Poznan, Poland

open access

Vol 72, No 5 (2022)
Original article
Published online: 2022-08-26

Abstract

Introduction.Breast cancer is the most common cancer among women in Poland. The aim of this study was to evalu­ate the incidence of cardiotoxicity in patients treated with adjunctive trastuzumab, as well as to determine risk factors for cardiotoxicity.

Material and methods.The study covered 100 patients who completed one year of trastuzumab therapy or discon­tinued treatment due to acute cardiac complications. They underwent an oncological, cardiological, questionnaire and laboratory follow-up.

Results.Acute cardiac complications (CC(+)) occurred in 11 (11%) patients. Patients in the CC(+) group were more likely to have hypertension, ischemic heart disease, hypothyroidism, and were more likely to smoke compared to the gro­up without cardiac complications (CC(–)). They had a lower left ventricular ejection fraction before, during and after trastuzumab therapy, and larger left ventricular dimensions in systole and diastole after treatment. The CC(+) received a higher dose of anthracyclines compared to CC(–). The NT-proBNP value remained elevated in the CC(+) group after treatment, despite normal LVEF values, and was higher than in the CC(–) group.

Conclusions.Based on the study, type II cardiotoxicity, diagnosed early and treated appropriately, was found to be reversible.

Abstract

Introduction.Breast cancer is the most common cancer among women in Poland. The aim of this study was to evalu­ate the incidence of cardiotoxicity in patients treated with adjunctive trastuzumab, as well as to determine risk factors for cardiotoxicity.

Material and methods.The study covered 100 patients who completed one year of trastuzumab therapy or discon­tinued treatment due to acute cardiac complications. They underwent an oncological, cardiological, questionnaire and laboratory follow-up.

Results.Acute cardiac complications (CC(+)) occurred in 11 (11%) patients. Patients in the CC(+) group were more likely to have hypertension, ischemic heart disease, hypothyroidism, and were more likely to smoke compared to the gro­up without cardiac complications (CC(–)). They had a lower left ventricular ejection fraction before, during and after trastuzumab therapy, and larger left ventricular dimensions in systole and diastole after treatment. The CC(+) received a higher dose of anthracyclines compared to CC(–). The NT-proBNP value remained elevated in the CC(+) group after treatment, despite normal LVEF values, and was higher than in the CC(–) group.

Conclusions.Based on the study, type II cardiotoxicity, diagnosed early and treated appropriately, was found to be reversible.

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Keywords

cardiotoxicity; anthracyclines; trastuzumab; breast cancer

About this article
Title

Cardiotoxicity in patients with early breast cancer treated with adjuvant trastuzumab

Journal

Nowotwory. Journal of Oncology

Issue

Vol 72, No 5 (2022)

Article type

Research paper (original)

Pages

288-293

Published online

2022-08-26

Page views

283

Article views/downloads

77

DOI

10.5603/NJO.a2022.0047

Bibliographic record

Nowotwory. Journal of Oncology 2022;72(5):288-293.

Keywords

cardiotoxicity
anthracyclines
trastuzumab
breast cancer

Authors

Joanna Kufel-Grabowska
Sławomir Katarzyński
Sebastian Szmit
Mikołaj Bartoszkiewicz
Maria Litwiniuk

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