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Vol 72, No 2 (2022)
Review paper
Published online: 2022-02-11
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Selected platinum complexes in standard and modern anti-cancer therapies
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Affiliations- Department of Medical Biology, Institute of Biology, Jan Kochanowski University, Kielce, Poland
open access
Vol 72, No 2 (2022)
Review article
Published online: 2022-02-11
Abstract
The constantly observed increase in the number of cancer cases inspires research aimed at searching for new compounds with anti-cancer potential. In recent years, much research has focused on platinum complexes, especially their anti-cancer properties. Platinum derivatives are characterized by high cytotoxic activity against many types of cancer cells. However, among the numerous developed complexes, only cisplatin, carboplatin and oxaliplatin have found wide application in chemotherapeutic treatment. Nedaplatin, lobaplatin and heptaplatin have also gained recognition, and have been implemented in oncological therapy in Japan, China and Korea. Some of the platinum complexes are still at the stage of pre-clinical and clinical trials. The aim of the research conducted today is to search for platinum compounds that show high pharmacological effectiveness, with clearly limited side effects. In future therapeutic strategies, the possibility of using platinum complexes in conjunction with other chemotherapeutic compounds is being considered, which may contribute to increasing the efficacy of anti-cancer therapy.
Abstract
The constantly observed increase in the number of cancer cases inspires research aimed at searching for new compounds with anti-cancer potential. In recent years, much research has focused on platinum complexes, especially their anti-cancer properties. Platinum derivatives are characterized by high cytotoxic activity against many types of cancer cells. However, among the numerous developed complexes, only cisplatin, carboplatin and oxaliplatin have found wide application in chemotherapeutic treatment. Nedaplatin, lobaplatin and heptaplatin have also gained recognition, and have been implemented in oncological therapy in Japan, China and Korea. Some of the platinum complexes are still at the stage of pre-clinical and clinical trials. The aim of the research conducted today is to search for platinum compounds that show high pharmacological effectiveness, with clearly limited side effects. In future therapeutic strategies, the possibility of using platinum complexes in conjunction with other chemotherapeutic compounds is being considered, which may contribute to increasing the efficacy of anti-cancer therapy.
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Keywords
cisplatin; platinum complexes; anticancer drugs; chemotherapy
About this articleTitle
Selected platinum complexes in standard and modern anti-cancer therapies
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
96-105
Published online
2022-02-11
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5017
Article views/downloads
609
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2022;72(2):96-105.
Keywords
cisplatin
platinum complexes
anticancer drugs
chemotherapy
Authors
Anna Kopacz-Bednarska
Teodora Król
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