The atypical form of granulomatous lobular mastitis – diagnostic dilemmas. A case report
Abstract
Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory condition that may cause diagnostic difficulties during clinical tests and radiological examinations in terms of differentiation from contagious diseases, such as tuberculosis (TB) and fungal infections, as well as cancer. This report presents the case of a 23-year-old woman with granulomatous mastitis, along with a discussion of the diagnostic dilemmas based on a clinical test, mammography, ultrasonography and histopathological examination. IGM produces varied and non-specific manifestations on mammography and ultrasonography. Therefore, histopathological examination is necessary to make an unambiguous diagnosis. The possibility of this condition must always be borne in mind to minimise the risk of an erroneous cancer diagnosis. There are no standard procedures in force for the treatment of IGM.
Keywords: granulomatous mastitisbreast cancer
References
- Garcia-Rodiguez JA, Pattullo A. Idiopathic granulomatous mastitis: a mimicking disease in a pregnant woman: a case report. BMC Res Notes. 2013; 6: 95.
- Kalaycı TÖ, Koruyucu MB, Apaydın M, et al. Idiopathic Granulomatous Mastitis Associated with Erythema Nodosum. Balkan Med J. 2016; 33(2): 228–231.
- Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol. 1972; 58(6): 642–646.
- Going JJ, Anderson TJ, Wilkinson S, et al. Granulomatous lobular mastitis. J Clin Pathol. 1987; 40(5): 535–540.
- Barreto DS, Sedgwick EL, Nagi CS, et al. Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. Breast Cancer Res Treat. 2018; 171(3): 527–534.
- Wolfrum A, Kümmel S, Theuerkauf I, et al. Granulomatous Mastitis: A Therapeutic and Diagnostic Challenge. Breast Care (Basel). 2018; 13(6): 413–418.
- Oberman HA. Invasive carcinoma of the breast with granulomatous response. Am J Clin Pathol. 1987; 88(6): 718–721.
- Gurleyik G, Aktekin A, Aker F, et al. Medical and surgical treatment of idiopathic granulomatous lobular mastitis: a benign inflammatory disease mimicking invasive carcinoma. J Breast Cancer. 2012; 15(1): 119–123.
- Jorgensen M, Nielsen D. Diagnosis and treatment of granulomatous mastitis. Am J Med. 1992; 93(1): 97–101.
- Akcan A, Akyildiz H, Deneme MA, et al. Granulomatous lobular mastitis: a complex diagnostic and therapeutic problem. World J Surg. 2006; 30(8): 1403–1409.
- Ergin AB, Cristofanilli M, Daw H, et al. Recurrent granulomatous mastitis mimicking inflammatory breast cancer. BMJ Case Rep. 2011; 2011.
- Patel RA, Strickland P, Sankara IR, et al. Idiopathic granulomatous mastitis: case reports and review of literature. J Gen Intern Med. 2010; 25(3): 270–273.
- Imoto S, Kitaya T, Kodama T, et al. Idiopathic granulomatous mastitis: case report and review of the literature. Jpn J Clin Oncol. 1997; 27(4): 274–277.
- Atak T, Sagiroglu J, Eren T, et al. Strategies to treat idiopathic granulomatous mastitis: retrospective analysis of 40 patients. Breast Dis. 2015; 35(1): 19–24.
- Sheybani F, Sarvghad M, Naderi H, et al. Treatment for and clinical characteristics of granulomatous mastitis. Obstet Gynecol. 2015; 125(4): 801–807.
- Mahmodlou R, Dadkhah N, Abbasi F, et al. Idiopathic granulomatous mastitis: dilemmas in diagnosis and treatment. Electron Physician. 2017; 9(9): 5375–5379.