open access

Vol 69, No 1 (2019)
Research paper (original)
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Can we predict lymph node metastasis by using preoperative markers in gastric cancer patients?

Mateusz Pryt, Marta Kalwas, Dariusz Nejc, Arkadiusz Jeziorski
DOI: 10.5603/NJO.2019.0002
·
Nowotwory. Journal of Oncology 2019;69(1):7-11.

open access

Vol 69, No 1 (2019)
Original article

Abstract

Introduction. Lymph node involvement is a negative prognostic factor for patients undergoing curative gastrectomy and indication for preoperative chemotherapy, thus a sufficient assessment strategy is required. We aimed to establish the value of preoperatively collected data in prediction of lymph node metastasis.
Material and methods. We conducted a retrospective analysis of 150 gastric cancer patients hospitalized in the Department of Surgical Oncology, Medical University of Łódź in 2011–2017. We gathered information comprising clinicopathological features, inflammatory markers: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic inflammatory response index (SIRI) and Tumor Index (TI).
Results. Independent factors associated with lymph node involvement were: NLR (OR = 1.35; p = 0.01), Tumor Index (OR = 1.07; p < 0.001). ROC curve plots assessed the diagnostic value of TI and NLR.
Conclusions. Tumor Index and NLR are factors indicating lymph node metastasis in gastric cancer patients. NLR is a potentially useful tool for neoadjuvant chemotherapy qualification.

Abstract

Introduction. Lymph node involvement is a negative prognostic factor for patients undergoing curative gastrectomy and indication for preoperative chemotherapy, thus a sufficient assessment strategy is required. We aimed to establish the value of preoperatively collected data in prediction of lymph node metastasis.
Material and methods. We conducted a retrospective analysis of 150 gastric cancer patients hospitalized in the Department of Surgical Oncology, Medical University of Łódź in 2011–2017. We gathered information comprising clinicopathological features, inflammatory markers: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic inflammatory response index (SIRI) and Tumor Index (TI).
Results. Independent factors associated with lymph node involvement were: NLR (OR = 1.35; p = 0.01), Tumor Index (OR = 1.07; p < 0.001). ROC curve plots assessed the diagnostic value of TI and NLR.
Conclusions. Tumor Index and NLR are factors indicating lymph node metastasis in gastric cancer patients. NLR is a potentially useful tool for neoadjuvant chemotherapy qualification.

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Keywords

gastric cancer, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymph node metastasis

About this article
Title

Can we predict lymph node metastasis by using preoperative markers in gastric cancer patients?

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 1 (2019)

Article type

Research paper (original)

Pages

7-11

DOI

10.5603/NJO.2019.0002

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(1):7-11.

Keywords

gastric cancer
neutrophil/lymphocyte ratio
platelet/lymphocyte ratio
lymph node metastasis

Authors

Mateusz Pryt
Marta Kalwas
Dariusz Nejc
Arkadiusz Jeziorski

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