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Can we predict lymph node metastasis by using preoperative markers in gastric cancer patients?
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Abstract
Introduction. Lymph node involvement is a negative prognostic factor for patients undergoing curative gastrectomy and indication for preoperative chemotherapy, thus a sufficient assessment strategy is required. We aimed to establish the value of preoperatively collected data in prediction of lymph node metastasis.
Material and methods. We conducted a retrospective analysis of 150 gastric cancer patients hospitalized in the Department of Surgical Oncology, Medical University of Łódź in 2011–2017. We gathered information comprising clinicopathological features, inflammatory markers: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic inflammatory response index (SIRI) and Tumor Index (TI).
Results. Independent factors associated with lymph node involvement were: NLR (OR = 1.35; p = 0.01), Tumor Index (OR = 1.07; p < 0.001). ROC curve plots assessed the diagnostic value of TI and NLR.
Conclusions. Tumor Index and NLR are factors indicating lymph node metastasis in gastric cancer patients. NLR is a potentially useful tool for neoadjuvant chemotherapy qualification.
Abstract
Introduction. Lymph node involvement is a negative prognostic factor for patients undergoing curative gastrectomy and indication for preoperative chemotherapy, thus a sufficient assessment strategy is required. We aimed to establish the value of preoperatively collected data in prediction of lymph node metastasis.
Material and methods. We conducted a retrospective analysis of 150 gastric cancer patients hospitalized in the Department of Surgical Oncology, Medical University of Łódź in 2011–2017. We gathered information comprising clinicopathological features, inflammatory markers: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic inflammatory response index (SIRI) and Tumor Index (TI).
Results. Independent factors associated with lymph node involvement were: NLR (OR = 1.35; p = 0.01), Tumor Index (OR = 1.07; p < 0.001). ROC curve plots assessed the diagnostic value of TI and NLR.
Conclusions. Tumor Index and NLR are factors indicating lymph node metastasis in gastric cancer patients. NLR is a potentially useful tool for neoadjuvant chemotherapy qualification.
Keywords
gastric cancer, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymph node metastasis
About this articleTitle
Can we predict lymph node metastasis by using preoperative markers in gastric cancer patients?
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
7-11
Published online
2019-06-18
Page views
757
Article views/downloads
577
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2019;69(1):7-11.
Keywords
gastric cancer
neutrophil/lymphocyte ratio
platelet/lymphocyte ratio
lymph node metastasis
Authors
Mateusz Pryt
Marta Kalwas
Dariusz Nejc
Arkadiusz Jeziorski