open access

Vol 68, No 5-6 (2018)
Other materials agreed with the Editors
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Pre- or postoperative chemotherapy in patients with colorectal cancer with synchronous, resectable liver metastases?

Rafał Stec
DOI: 10.5603/2018.0044
·
Nowotwory. Journal of Oncology 2018;68(5-6):277-281.

open access

Vol 68, No 5-6 (2018)
Short review

Abstract

At the moment, there is no clear scientific data on the use of preoperative chemotherapy in patients with colorectal, synchronous, resectable liver metastases. Below arguments are presented against the use of preoperative chemotherapy in the above clinical situation, based on an analysis of three issues: the toxicity of preoperative chemotherapy and associated perioperative complications, the efficacy of pre- and postoperative chemotherapy, doubts related to the use of preoperative chemotherapy. To summarise, most scientific data is against preoperative chemotherapy as it causes significant adverse effects (hepatotoxicity and consequent postoperative complications) without a significant improvement in survival rates. Therefore, postoperative chemotherapy in this group of patients seems to be the more optimal treatment.

Abstract

At the moment, there is no clear scientific data on the use of preoperative chemotherapy in patients with colorectal, synchronous, resectable liver metastases. Below arguments are presented against the use of preoperative chemotherapy in the above clinical situation, based on an analysis of three issues: the toxicity of preoperative chemotherapy and associated perioperative complications, the efficacy of pre- and postoperative chemotherapy, doubts related to the use of preoperative chemotherapy. To summarise, most scientific data is against preoperative chemotherapy as it causes significant adverse effects (hepatotoxicity and consequent postoperative complications) without a significant improvement in survival rates. Therefore, postoperative chemotherapy in this group of patients seems to be the more optimal treatment.

Get Citation

Keywords

colorectal cancer; synchronous liver metastases; preoperative chemotherapy; adjuvant chemotherapy

About this article
Title

Pre- or postoperative chemotherapy in patients with colorectal cancer with synchronous, resectable liver metastases?

Journal

Nowotwory. Journal of Oncology

Issue

Vol 68, No 5-6 (2018)

Article type

Other materials agreed with the Editors

Pages

277-281

DOI

10.5603/2018.0044

Bibliographic record

Nowotwory. Journal of Oncology 2018;68(5-6):277-281.

Keywords

colorectal cancer
synchronous liver metastases
preoperative chemotherapy
adjuvant chemotherapy

Authors

Rafał Stec

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