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Pre- or postoperative chemotherapy in patients with colorectal cancer with synchronous, resectable liver metastases?
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Abstract
At the moment, there is no clear scientific data on the use of preoperative chemotherapy in patients with colorectal, synchronous, resectable liver metastases. Below arguments are presented against the use of preoperative chemotherapy in the above clinical situation, based on an analysis of three issues: the toxicity of preoperative chemotherapy and associated perioperative complications, the efficacy of pre- and postoperative chemotherapy, doubts related to the use of preoperative chemotherapy. To summarise, most scientific data is against preoperative chemotherapy as it causes significant adverse effects (hepatotoxicity and consequent postoperative complications) without a significant improvement in survival rates. Therefore, postoperative chemotherapy in this group of patients seems to be the more optimal treatment.
Abstract
At the moment, there is no clear scientific data on the use of preoperative chemotherapy in patients with colorectal, synchronous, resectable liver metastases. Below arguments are presented against the use of preoperative chemotherapy in the above clinical situation, based on an analysis of three issues: the toxicity of preoperative chemotherapy and associated perioperative complications, the efficacy of pre- and postoperative chemotherapy, doubts related to the use of preoperative chemotherapy. To summarise, most scientific data is against preoperative chemotherapy as it causes significant adverse effects (hepatotoxicity and consequent postoperative complications) without a significant improvement in survival rates. Therefore, postoperative chemotherapy in this group of patients seems to be the more optimal treatment.
Keywords
colorectal cancer; synchronous liver metastases; preoperative chemotherapy; adjuvant chemotherapy
About this articleTitle
Pre- or postoperative chemotherapy in patients with colorectal cancer with synchronous, resectable liver metastases?
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Other materials agreed with the Editors
Pages
277-281
Published online
2019-05-07
Page views
330
Article views/downloads
431
DOI
10.5603/2018.0044
Bibliographic record
Nowotwory. Journal of Oncology 2018;68(5-6):277-281.
Keywords
colorectal cancer
synchronous liver metastases
preoperative chemotherapy
adjuvant chemotherapy
Authors
Rafał Stec