open access

Vol 68, No 3 (2018)
Short reviews
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Adjuvant chemotherapy in the patients with rectal cancer after neoadjuvant chemoradiotherapy and radical resection — YES

Rafał Stec
Nowotwory. Journal of Oncology 2018;68(3):152-156.

open access

Vol 68, No 3 (2018)
Short reviews

Abstract

At the moment there are some scientific data supporting the use of adjuvant chemotherapy in patients with rectal cancer after neoadjuvant chemoradiotherapy and surgical treatment. The paper below presents some arguments for the use of adjuvant chemotherapy in the above clinical situation. The majority of deaths in patients with rectal cancer are caused by the presence of distant metastases, therefore there are significant grounds for the use of adjuvant che­motherapy in this group of patients. Summarising, there is no clear or scientific evidence against the use of adjuvant chemotherapy in patients with rectal cancer after preoperative chemoradiotherapy. In order to make a conclusive statement about the lack of any benefits from adjuvant therapy, it is necessary to carry out randomised studies on a homogeneous and standardised group of patients. Therefore, it seems appropriate to apply this therapy especially for patients with the N (+) features (with a tumour location between 10 cm and 15 cm), similar to colon cancer cases.

Abstract

At the moment there are some scientific data supporting the use of adjuvant chemotherapy in patients with rectal cancer after neoadjuvant chemoradiotherapy and surgical treatment. The paper below presents some arguments for the use of adjuvant chemotherapy in the above clinical situation. The majority of deaths in patients with rectal cancer are caused by the presence of distant metastases, therefore there are significant grounds for the use of adjuvant che­motherapy in this group of patients. Summarising, there is no clear or scientific evidence against the use of adjuvant chemotherapy in patients with rectal cancer after preoperative chemoradiotherapy. In order to make a conclusive statement about the lack of any benefits from adjuvant therapy, it is necessary to carry out randomised studies on a homogeneous and standardised group of patients. Therefore, it seems appropriate to apply this therapy especially for patients with the N (+) features (with a tumour location between 10 cm and 15 cm), similar to colon cancer cases.

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Keywords

rectal cancer, preoperative chemoradiotherapy, surgical treatment, adjuvant chemotherapy

About this article
Title

Adjuvant chemotherapy in the patients with rectal cancer after neoadjuvant chemoradiotherapy and radical resection — YES

Journal

Nowotwory. Journal of Oncology

Issue

Vol 68, No 3 (2018)

Pages

152-156

Bibliographic record

Nowotwory. Journal of Oncology 2018;68(3):152-156.

Keywords

rectal cancer
preoperative chemoradiotherapy
surgical treatment
adjuvant chemotherapy

Authors

Rafał Stec

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