open access

Vol 67, No 6 (2017)
Research paper (original)
Published online: 2018-05-23
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Synchronous malignancies in patients with breast cancer

Beata Sas-Korczyńska, Jerzy W. Mituś, Wojciech Kamzol, Marta Kołodziej Rzepa, Jerzy Jakubowicz, Wojciech M. Wysocki
DOI: 10.5603/NJO.2017.0055
·
Nowotwory. Journal of Oncology 2017;67(6):336-341.

open access

Vol 67, No 6 (2017)
Original article
Published online: 2018-05-23

Abstract

Introduction. The continuously improving cancer detection at an early stage and improving survival rates have been observed and, therefore, patients are predisposed to detection of multiple primaries. It has been reported that the incidence of multiple primaries in breast cancer patients ranges from of 4% to 17%. Materials and methods. A group of 112 breast cancer patients with synchronous malignancies was presented. They constituted 0.09% of patients (118,952 cases) who were treated for breast cancer at the same time period, and made up 3.5% of all patients (3,176 cases) with multiple primary cancers, and 21.7% of all patients (517 cases) with breast cancer who developed multiple primaries. Results. The most frequent type of synchronous primary malignancy was breast cancer (63.4%) and 90.1% of them were diagnosed at the same time or within one month following the first breast cancer diagnosis. Among cases of non-breast synchronous primaries, female genital organ malignancies were predominant (36.6%). Synchronous breast cancer was diagnosed significantly earlier than non-breast cancers (mean time was 0.4 and 1 month, respectively, p = 0.0123). Better results in the group with synchronous contralateral breast cancer in comparison to synchronous breast and non-breast cancer were observed (5-year overall survival rates were 90.9% and 66.3%, respectively, and 5-year disease-free survival rate — 62.5% and 51.3%, respectively).

Abstract

Introduction. The continuously improving cancer detection at an early stage and improving survival rates have been observed and, therefore, patients are predisposed to detection of multiple primaries. It has been reported that the incidence of multiple primaries in breast cancer patients ranges from of 4% to 17%. Materials and methods. A group of 112 breast cancer patients with synchronous malignancies was presented. They constituted 0.09% of patients (118,952 cases) who were treated for breast cancer at the same time period, and made up 3.5% of all patients (3,176 cases) with multiple primary cancers, and 21.7% of all patients (517 cases) with breast cancer who developed multiple primaries. Results. The most frequent type of synchronous primary malignancy was breast cancer (63.4%) and 90.1% of them were diagnosed at the same time or within one month following the first breast cancer diagnosis. Among cases of non-breast synchronous primaries, female genital organ malignancies were predominant (36.6%). Synchronous breast cancer was diagnosed significantly earlier than non-breast cancers (mean time was 0.4 and 1 month, respectively, p = 0.0123). Better results in the group with synchronous contralateral breast cancer in comparison to synchronous breast and non-breast cancer were observed (5-year overall survival rates were 90.9% and 66.3%, respectively, and 5-year disease-free survival rate — 62.5% and 51.3%, respectively).

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Keywords

synchronous malignancies, breast cancer, contralateral breast cancer

About this article
Title

Synchronous malignancies in patients with breast cancer

Journal

Nowotwory. Journal of Oncology

Issue

Vol 67, No 6 (2017)

Article type

Research paper (original)

Pages

336-341

Published online

2018-05-23

DOI

10.5603/NJO.2017.0055

Bibliographic record

Nowotwory. Journal of Oncology 2017;67(6):336-341.

Keywords

synchronous malignancies
breast cancer
contralateral breast cancer

Authors

Beata Sas-Korczyńska
Jerzy W. Mituś
Wojciech Kamzol
Marta Kołodziej Rzepa
Jerzy Jakubowicz
Wojciech M. Wysocki

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