open access

Vol 67, No 4 (2017)
Review paper
Published online: 2017-12-29
Get Citation

Circulating tumor cells and their clinical significance

Ewa Anna Grzybowska, Anna Fabisiewicz
DOI: 10.5603/NJO.2017.0039
·
Nowotwory. Journal of Oncology 2017;67(4):243-250.

open access

Vol 67, No 4 (2017)
Review article
Published online: 2017-12-29

Abstract

Metastases to other organs and the formation of secondary tumors are responsible for 90% of cancer-related deaths. However, even in the early stages of cancer, about 30–40% of patients with localized disease may have latent metastasis, which are likely derived from circulating tumor cells (CTCs) involved in disease progression. Therefore, detection and analysis of CTCs can play an important role in the diagnosis and decision-making of adjuvant treat­ment that aims to prevent metastasis. At present, patients’ selection of treatment is based on the statistical risk of recurrence of metastatic disease, without considering whether the tumor cells have spread from the primary tumor. This may lead to unnecessary treatment of non-metastatic disease patients. Therefore, early detection of CTCs in the blood is critically important, and should allow for a more accurate assessment of disease severity. Here, we provide an overview of CTC phenotypes, including plasticity of CTCs, and their clinical significance.

Abstract

Metastases to other organs and the formation of secondary tumors are responsible for 90% of cancer-related deaths. However, even in the early stages of cancer, about 30–40% of patients with localized disease may have latent metastasis, which are likely derived from circulating tumor cells (CTCs) involved in disease progression. Therefore, detection and analysis of CTCs can play an important role in the diagnosis and decision-making of adjuvant treat­ment that aims to prevent metastasis. At present, patients’ selection of treatment is based on the statistical risk of recurrence of metastatic disease, without considering whether the tumor cells have spread from the primary tumor. This may lead to unnecessary treatment of non-metastatic disease patients. Therefore, early detection of CTCs in the blood is critically important, and should allow for a more accurate assessment of disease severity. Here, we provide an overview of CTC phenotypes, including plasticity of CTCs, and their clinical significance.

Get Citation

Keywords

CTC, metastasis

About this article
Title

Circulating tumor cells and their clinical significance

Journal

Nowotwory. Journal of Oncology

Issue

Vol 67, No 4 (2017)

Article type

Review paper

Pages

243-250

Published online

2017-12-29

DOI

10.5603/NJO.2017.0039

Bibliographic record

Nowotwory. Journal of Oncology 2017;67(4):243-250.

Keywords

CTC
metastasis

Authors

Ewa Anna Grzybowska
Anna Fabisiewicz

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