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Insights into etiological factors of pulmonary hypertension in cancer patients
Affiliations- Medical Oncology and Clinical Trials Department, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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Abstract
Pulmonary hypertension is a rare vascular disease that can affect patients with or surviving malignancy resulting in significant morbidity and high mortality. Malignant diseases can lead to elevated pulmonary artery pressure through different mechanisms, either directly by structural obstruction of pulmonary vessels or indirectly through hypercoagulable state or treatment toxicity culminating in high pulmonary vascular resistance. The most common causes of cancer-related pulmonary hypertension are thromboembolic diseases, tumour emboli and treatment toxicity and less commonly intravascular tumours and malignant extrinsic compression.
Abstract
Pulmonary hypertension is a rare vascular disease that can affect patients with or surviving malignancy resulting in significant morbidity and high mortality. Malignant diseases can lead to elevated pulmonary artery pressure through different mechanisms, either directly by structural obstruction of pulmonary vessels or indirectly through hypercoagulable state or treatment toxicity culminating in high pulmonary vascular resistance. The most common causes of cancer-related pulmonary hypertension are thromboembolic diseases, tumour emboli and treatment toxicity and less commonly intravascular tumours and malignant extrinsic compression.
Keywords
pulmonary hypertension, pulmonary arterial hypertension, pulmonary veno-occlusive disease, cancer, chemotherapy, cardiac toxicity
About this articleTitle
Insights into etiological factors of pulmonary hypertension in cancer patients
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
236-242
Published online
2017-12-29
Page views
766
Article views/downloads
991
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2017;67(4):236-242.
Keywords
pulmonary hypertension
pulmonary arterial hypertension
pulmonary veno-occlusive disease
cancer
chemotherapy
cardiac toxicity
Authors
Loma Al-Mansouri
Firas Al-Obaidi