open access

Vol 67, No 4 (2017)
Review paper
Published online: 2017-12-29
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Insights into etiological factors of pulmonary hypertension in cancer patients

Loma Al-Mansouri, Firas Al-Obaidi
DOI: 10.5603/NJO.2017.0038
·
Nowotwory. Journal of Oncology 2017;67(4):236-242.

open access

Vol 67, No 4 (2017)
Review article
Published online: 2017-12-29

Abstract

Pulmonary hypertension is a rare vascular disease that can affect patients with or surviving malignancy resulting in significant morbidity and high mortality. Malignant diseases can lead to elevated pulmonary artery pressure through different mechanisms, either directly by structural obstruction of pulmonary vessels or indirectly through hyperco­agulable state or treatment toxicity culminating in high pulmonary vascular resistance. The most common causes of cancer-related pulmonary hypertension are thromboembolic diseases, tumour emboli and treatment toxicity and less commonly intravascular tumours and malignant extrinsic compression.

Abstract

Pulmonary hypertension is a rare vascular disease that can affect patients with or surviving malignancy resulting in significant morbidity and high mortality. Malignant diseases can lead to elevated pulmonary artery pressure through different mechanisms, either directly by structural obstruction of pulmonary vessels or indirectly through hyperco­agulable state or treatment toxicity culminating in high pulmonary vascular resistance. The most common causes of cancer-related pulmonary hypertension are thromboembolic diseases, tumour emboli and treatment toxicity and less commonly intravascular tumours and malignant extrinsic compression.

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Keywords

pulmonary hypertension, pulmonary arterial hypertension, pulmonary veno-occlusive disease, cancer, chemotherapy, cardiac toxicity

About this article
Title

Insights into etiological factors of pulmonary hypertension in cancer patients

Journal

Nowotwory. Journal of Oncology

Issue

Vol 67, No 4 (2017)

Article type

Review paper

Pages

236-242

Published online

2017-12-29

DOI

10.5603/NJO.2017.0038

Bibliographic record

Nowotwory. Journal of Oncology 2017;67(4):236-242.

Keywords

pulmonary hypertension
pulmonary arterial hypertension
pulmonary veno-occlusive disease
cancer
chemotherapy
cardiac toxicity

Authors

Loma Al-Mansouri
Firas Al-Obaidi

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