open access

Vol 65, No 6 (2015)
Review paper
Published online: 2016-02-05
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Ruthenium coordination compounds as drugs in modern anticancer therapy

Urszula Śliwińska-Hill, Joanna Celmer
DOI: 10.5603/NJO.2015.0107
·
Nowotwory. Journal of Oncology 2015;65(6):517-528.

open access

Vol 65, No 6 (2015)
Review article
Published online: 2016-02-05

Abstract

The study of metal coordination compounds for the treatment of cancer has resulted in the identification of some unique properties of ruthenium complexes as antitumour agents. Among these group two of them, NAMI-A and KP1019 have entered the clinical trials with patients. The studies showed that NAMI-A inhibits the formation of metastases and KP1019 demonstrates exciting anticancer activities especially in colorectal carcinoma. As well as these two compounds, organometallic ruthenium-based complexes RM175, RAPTA-T, RDC11 and DW1/2 are very promising in the antitumour therapy.

Abstract

The study of metal coordination compounds for the treatment of cancer has resulted in the identification of some unique properties of ruthenium complexes as antitumour agents. Among these group two of them, NAMI-A and KP1019 have entered the clinical trials with patients. The studies showed that NAMI-A inhibits the formation of metastases and KP1019 demonstrates exciting anticancer activities especially in colorectal carcinoma. As well as these two compounds, organometallic ruthenium-based complexes RM175, RAPTA-T, RDC11 and DW1/2 are very promising in the antitumour therapy.

Get Citation
About this article
Title

Ruthenium coordination compounds as drugs in modern anticancer therapy

Journal

Nowotwory. Journal of Oncology

Issue

Vol 65, No 6 (2015)

Article type

Review paper

Pages

517-528

Published online

2016-02-05

DOI

10.5603/NJO.2015.0107

Bibliographic record

Nowotwory. Journal of Oncology 2015;65(6):517-528.

Authors

Urszula Śliwińska-Hill
Joanna Celmer

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