open access
Vol 63, No 1 (2013)
Review paper
Published online: 2013-03-08
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The use of radical proton beam radiotherapy for stage I–III non-small-cell lung cancer patients
, ,
Nowotwory. Journal of Oncology 2013;63(1):48-57.
open access
Vol 63, No 1 (2013)
Review article
Published online: 2013-03-08
Abstract
Surgery is the treatment of choice for patients with early-stage non-small-cell lung cancer. A proportion of patients
cannot undergo surgery due to comorbid conditions and — in this situation — radical radiotherapy may be an alternative
method of treatment. Compared with conventional photon irradiation proton beam treatment — either
three-dimensional conformal or intensity-modulated radiation therapy — allows for dose escalation with reduction of
the dose delivered to normal tissues. Proton beam therapy is safe and effective for treating patients with non-small-cell
lung cancer. Clinical studies confirm the feasibility of proton irradiation for early-stage non-small-cell lung cancers
and further trials are being performed in locally advanced tumors. In this paper, we present the physical aspects and
the preliminary data from dosimetric and clinical studies for proton beam therapy in stage I–III non-small-cell lung
cancer on the basis of the available literature.
cannot undergo surgery due to comorbid conditions and — in this situation — radical radiotherapy may be an alternative
method of treatment. Compared with conventional photon irradiation proton beam treatment — either
three-dimensional conformal or intensity-modulated radiation therapy — allows for dose escalation with reduction of
the dose delivered to normal tissues. Proton beam therapy is safe and effective for treating patients with non-small-cell
lung cancer. Clinical studies confirm the feasibility of proton irradiation for early-stage non-small-cell lung cancers
and further trials are being performed in locally advanced tumors. In this paper, we present the physical aspects and
the preliminary data from dosimetric and clinical studies for proton beam therapy in stage I–III non-small-cell lung
cancer on the basis of the available literature.
Abstract
Surgery is the treatment of choice for patients with early-stage non-small-cell lung cancer. A proportion of patients
cannot undergo surgery due to comorbid conditions and — in this situation — radical radiotherapy may be an alternative
method of treatment. Compared with conventional photon irradiation proton beam treatment — either
three-dimensional conformal or intensity-modulated radiation therapy — allows for dose escalation with reduction of
the dose delivered to normal tissues. Proton beam therapy is safe and effective for treating patients with non-small-cell
lung cancer. Clinical studies confirm the feasibility of proton irradiation for early-stage non-small-cell lung cancers
and further trials are being performed in locally advanced tumors. In this paper, we present the physical aspects and
the preliminary data from dosimetric and clinical studies for proton beam therapy in stage I–III non-small-cell lung
cancer on the basis of the available literature.
cannot undergo surgery due to comorbid conditions and — in this situation — radical radiotherapy may be an alternative
method of treatment. Compared with conventional photon irradiation proton beam treatment — either
three-dimensional conformal or intensity-modulated radiation therapy — allows for dose escalation with reduction of
the dose delivered to normal tissues. Proton beam therapy is safe and effective for treating patients with non-small-cell
lung cancer. Clinical studies confirm the feasibility of proton irradiation for early-stage non-small-cell lung cancers
and further trials are being performed in locally advanced tumors. In this paper, we present the physical aspects and
the preliminary data from dosimetric and clinical studies for proton beam therapy in stage I–III non-small-cell lung
cancer on the basis of the available literature.
Get Citation
About this articleTitle
The use of radical proton beam radiotherapy for stage I–III non-small-cell lung cancer patients
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
48-57
Published online
2013-03-08
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Bibliographic record
Nowotwory. Journal of Oncology 2013;63(1):48-57.
Authors
Dorota Kwapisz
Andrzej Kawecki
Maciej Krzakowski