open access

Vol 69, No 2 (2019)
Case report
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Three secondary malignant neoplasms in a childhood cancer survivor positive for nibrin gene mutation – a case report and literature review

Anna Romanowska, Joanna Gajda, Jacek Jassem, Rafał Pęksa, Renata Zaucha
DOI: 10.5603/2019.0012
·
Nowotwory. Journal of Oncology 2019;69(2):65-66.

open access

Vol 69, No 2 (2019)
Case report

Abstract

Childhood cancer survivors often develop subsequent neoplasms secondary to radio- (RT) or chemotherapy (CHT). Risk factors for the secondary tumors are the female gender, older age at diagnosis, Hodgkin’s lymphoma treatment and the use of RT. The cumulative incidence of the second malignant neoplasm, excluding non-melanoma skin cancer, 30 years after the childhood cancer diagnosis is around 8% [1]. We present the case of a patient who developed three independent malignancies following radical treatment of nephroblastoma (Wilms’ tumor; WT) in childhood, found at the age of 53 to be a carrier of the 657_661delACAAA (p. Lys219fs) mutation in the 6/16 exon of the nibrin coding gene (NBN).

Abstract

Childhood cancer survivors often develop subsequent neoplasms secondary to radio- (RT) or chemotherapy (CHT). Risk factors for the secondary tumors are the female gender, older age at diagnosis, Hodgkin’s lymphoma treatment and the use of RT. The cumulative incidence of the second malignant neoplasm, excluding non-melanoma skin cancer, 30 years after the childhood cancer diagnosis is around 8% [1]. We present the case of a patient who developed three independent malignancies following radical treatment of nephroblastoma (Wilms’ tumor; WT) in childhood, found at the age of 53 to be a carrier of the 657_661delACAAA (p. Lys219fs) mutation in the 6/16 exon of the nibrin coding gene (NBN).

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Keywords

leiomyosarcoma, secondary neoplasms, radiotherapy, nibrin

About this article
Title

Three secondary malignant neoplasms in a childhood cancer survivor positive for nibrin gene mutation – a case report and literature review

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 2 (2019)

Pages

65-66

DOI

10.5603/2019.0012

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(2):65-66.

Keywords

leiomyosarcoma
secondary neoplasms
radiotherapy
nibrin

Authors

Anna Romanowska
Joanna Gajda
Jacek Jassem
Rafał Pęksa
Renata Zaucha

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